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Among tumors, most cases showed moderate cytoplasmic staining, often combined with membranous immunoreactivity. Colorectal cancers and cholangiocarcinomas showed strong positivity, while most prostate and urothelial cancers were negative.
Breast cancers exhibited a differential staining pattern ranging from negative to strong. Isolated cases of gliomas, melanomas, prostate and urothelial cancers displayed moderate to strong immunoreactivity. The remaining malignant tissues were mainly negative.
GENE INFORMATION
Gene name
SCUBE2 (HGNC Symbol)
Synonyms
Cegb1, Cegf1, FLJ16792
Description
Signal peptide, CUB domain, EGF-like 2 (HGNC Symbol)