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RAB6A

CANCER ATLAS

Gene description

 RAB6A, member RAS oncogene family

Protein class

 Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA059131
CAB009936

GENE INFORMATION

Gene name

 RAB6A (HGNC Symbol)

Synonyms

 RAB6

Description

 RAB6A, member RAS oncogene family (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the RAB family, which belongs to the small GTPase superfamily. GTPases of the RAB family bind to various effectors to regulate the targeting and fusion of transport carriers to acceptor compartments. This protein is located at the Golgi apparatus, which regulates trafficking in both a retrograde (from early endosomes and Golgi to the endoplasmic reticulum) and an anterograde (from the Golgi to the plasma membrane) directions. Myosin II is an effector of this protein in these processes. This protein is also involved in assembly of human cytomegalovirus (HCMV) by interacting with the cellular protein Bicaudal D1, which interacts with the HCMV virion tegument protein, pp150. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]

Chromosome

 11

Cytoband

 q13.4

Chromosome location (bp)

 73675638 - 73761137

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000175582 (version 83.38)

Entrez gene

 5870

UniProt

 P20340 (UniProt - Evidence at protein level)

neXtProt

 NX_P20340

Antibodypedia

 RAB6A antibodies

PROTEIN BROWSER
RAB6A-001
RAB6A-002
RAB6A-006
RAB6A-013
RAB6A-014
RAB6A-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RAB6A-001
ENSP00000311449
ENST00000310653
P20340 [Direct mapping]
Ras-related protein Rab-6A
A0A024R5H8 [Target identity:100%; Query identity:100%]
RAB6A, member RAS oncogene family, isoform CRA_b
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000042 [protein targeting to Golgi]
GO:0000139 [Golgi membrane]
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005794 [Golgi apparatus]
GO:0005802 [trans-Golgi network]
GO:0005829 [cytosol]
GO:0006886 [intracellular protein transport]
GO:0006890 [retrograde vesicle-mediated transport, Golgi to ER]
GO:0006913 [nucleocytoplasmic transport]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0018125 [peptidyl-cysteine methylation]
GO:0019882 [antigen processing and presentation]
GO:0019904 [protein domain specific binding]
GO:0031410 [cytoplasmic vesicle]
GO:0031489 [myosin V binding]
GO:0032482 [Rab protein signal transduction]
GO:0034067 [protein localization to Golgi apparatus]
GO:0034498 [early endosome to Golgi transport]
GO:0070062 [extracellular exosome]
GO:0070381 [endosome to plasma membrane transport vesicle]
GO:0072385 [minus-end-directed organelle transport along microtubule]
Show all
 208 aa
23.5 kDa 		No 0
RAB6A-002
ENSP00000336850
ENST00000336083
P20340 [Direct mapping]
Ras-related protein Rab-6A
A0A024R5J5 [Target identity:100%; Query identity:100%]
H.sapiens ras-related Hrab6 protein; RAB6A, member RAS oncogene family, isoform CRA_a
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000042 [protein targeting to Golgi]
GO:0000139 [Golgi membrane]
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005794 [Golgi apparatus]
GO:0005802 [trans-Golgi network]
GO:0005829 [cytosol]
GO:0006886 [intracellular protein transport]
GO:0006890 [retrograde vesicle-mediated transport, Golgi to ER]
GO:0006913 [nucleocytoplasmic transport]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0018125 [peptidyl-cysteine methylation]
GO:0019882 [antigen processing and presentation]
GO:0019904 [protein domain specific binding]
GO:0031410 [cytoplasmic vesicle]
GO:0031489 [myosin V binding]
GO:0032482 [Rab protein signal transduction]
GO:0034067 [protein localization to Golgi apparatus]
GO:0034498 [early endosome to Golgi transport]
GO:0070062 [extracellular exosome]
GO:0070381 [endosome to plasma membrane transport vesicle]
GO:0072385 [minus-end-directed organelle transport along microtubule]
Show all
 208 aa
23.6 kDa 		No 0
RAB6A-006
ENSP00000443782
ENST00000541973
P20340 [Direct mapping]
Ras-related protein Rab-6A
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000042 [protein targeting to Golgi]
GO:0000139 [Golgi membrane]
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005794 [Golgi apparatus]
GO:0005802 [trans-Golgi network]
GO:0005829 [cytosol]
GO:0006886 [intracellular protein transport]
GO:0006890 [retrograde vesicle-mediated transport, Golgi to ER]
GO:0006913 [nucleocytoplasmic transport]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0018125 [peptidyl-cysteine methylation]
GO:0019882 [antigen processing and presentation]
GO:0019904 [protein domain specific binding]
GO:0031410 [cytoplasmic vesicle]
GO:0031489 [myosin V binding]
GO:0032482 [Rab protein signal transduction]
GO:0034067 [protein localization to Golgi apparatus]
GO:0034498 [early endosome to Golgi transport]
GO:0070062 [extracellular exosome]
GO:0070381 [endosome to plasma membrane transport vesicle]
GO:0072385 [minus-end-directed organelle transport along microtubule]
Show all
 175 aa
19.9 kDa 		No 0
RAB6A-013
ENSP00000445350
ENST00000541588
P20340 [Direct mapping]
Ras-related protein Rab-6A
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000042 [protein targeting to Golgi]
GO:0000139 [Golgi membrane]
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005794 [Golgi apparatus]
GO:0005802 [trans-Golgi network]
GO:0005829 [cytosol]
GO:0006890 [retrograde vesicle-mediated transport, Golgi to ER]
GO:0007264 [small GTPase mediated signal transduction]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0018125 [peptidyl-cysteine methylation]
GO:0019882 [antigen processing and presentation]
GO:0019904 [protein domain specific binding]
GO:0031410 [cytoplasmic vesicle]
GO:0031489 [myosin V binding]
GO:0032482 [Rab protein signal transduction]
GO:0034067 [protein localization to Golgi apparatus]
GO:0034498 [early endosome to Golgi transport]
GO:0070062 [extracellular exosome]
GO:0070381 [endosome to plasma membrane transport vesicle]
GO:0072385 [minus-end-directed organelle transport along microtubule]
Show all
 104 aa
11.7 kDa 		No 0
RAB6A-014
ENSP00000438842
ENST00000540771
F5H3K7 [Direct mapping]
Ras-related protein Rab-6A
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0007264 [small GTPase mediated signal transduction]
GO:0032482 [Rab protein signal transduction]
Show all
 71 aa
8.1 kDa 		No 0
RAB6A-201
ENSP00000437863
ENST00000536566
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005525 [GTP binding]
GO:0007264 [small GTPase mediated signal transduction]
GO:0015031 [protein transport]
Show all
 87 aa
9.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.