Few cases of colorectal, gynaecological, gastric, pancreas, liver cancers, squamous cell carcinomas and malignant melanomas showed distinct nuclear positivity. Remaining malignancies were weakly stained or negative.
FOSL1 (HGNC Symbol)
FOS-like antigen 1 (HGNC Symbol)
Entrez gene summary
The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
Predicted intracellular proteins Plasma proteins Transcription factors Basic domains Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)