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Few cases of colorectal, gynaecological, gastric, pancreas, liver cancers, squamous cell carcinomas and malignant melanomas showed distinct nuclear positivity. Remaining malignancies were weakly stained or negative.
GENE INFORMATION
Gene name
FOSL1 (HGNC Symbol)
Synonyms
fra-1
Description
FOS-like antigen 1 (HGNC Symbol)
Entrez gene summary
The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
Predicted intracellular proteins Plasma proteins Transcription factors Basic domains Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0000982 [transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0001701 [in utero embryonic development] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005829 [cytosol] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0006366 [transcription from RNA polymerase II promoter] GO:0006935 [chemotaxis] GO:0006968 [cellular defense response] GO:0007296 [vitellogenesis] GO:0007565 [female pregnancy] GO:0007612 [learning] GO:0008284 [positive regulation of cell proliferation] GO:0008285 [negative regulation of cell proliferation] GO:0009612 [response to mechanical stimulus] GO:0009615 [response to virus] GO:0009629 [response to gravity] GO:0014070 [response to organic cyclic compound] GO:0031668 [cellular response to extracellular stimulus] GO:0032570 [response to progesterone] GO:0034097 [response to cytokine] GO:0042493 [response to drug] GO:0042542 [response to hydrogen peroxide] GO:0042734 [presynaptic membrane] GO:0043005 [neuron projection] GO:0043065 [positive regulation of apoptotic process] GO:0043231 [intracellular membrane-bounded organelle] GO:0043565 [sequence-specific DNA binding] GO:0045787 [positive regulation of cell cycle] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity] GO:0051412 [response to corticosterone] GO:0051591 [response to cAMP] GO:0060674 [placenta blood vessel development] GO:2000144 [positive regulation of DNA-templated transcription, initiation]
Predicted intracellular proteins Plasma proteins Transcription factors Basic domains Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014)
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GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0000982 [transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0006366 [transcription from RNA polymerase II promoter] GO:0006935 [chemotaxis] GO:0006968 [cellular defense response] GO:0008284 [positive regulation of cell proliferation] GO:0009615 [response to virus] GO:2000144 [positive regulation of DNA-templated transcription, initiation]
