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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Tissue

Detectable

Cell line

Detectable

Category

Score

Score

Score

Antibodies

Column

 
 
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FOSL1
  • TISSUE

  • premium

    CELL

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CANCER ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

CANCER ATLAS

Gene description

FOS-like antigen 1

Protein class

Cancer-related genes, Plasma proteins, Predicted intracellular proteins, Transcription factors

Protein evidence

Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

CAB004396

Tissue

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Tissue

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Few cases of colorectal, gynaecological, gastric, pancreas, liver cancers, squamous cell carcinomas and malignant melanomas showed distinct nuclear positivity. Remaining malignancies were weakly stained or negative.

GENE INFORMATION

Gene name

FOSL1 (HGNC Symbol)

Synonyms

fra-1

Description

FOS-like antigen 1 (HGNC Symbol)

Entrez gene summary

The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]

Chromosome

11

Cytoband

q13.1

Chromosome location (bp)

65892049 - 65900573

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000175592 (version 83.38)

Entrez gene

8061

UniProt

P15407 (UniProt - Evidence at protein level)

neXtProt

NX_P15407

Antibodypedia

FOSL1 antibodies

PROTEIN BROWSER

FOSL1-001
FOSL1-002
FOSL1-004
FOSL1-005
FOSL1-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

FOSL1-001
ENSP00000310170
ENST00000312562
P15407 [Direct mapping]
Fos-related antigen 1
Show all
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Basic domains
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0000982 [transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001701 [in utero embryonic development]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006935 [chemotaxis]
GO:0006968 [cellular defense response]
GO:0007296 [vitellogenesis]
GO:0007565 [female pregnancy]
GO:0007612 [learning]
GO:0008284 [positive regulation of cell proliferation]
GO:0008285 [negative regulation of cell proliferation]
GO:0009612 [response to mechanical stimulus]
GO:0009615 [response to virus]
GO:0009629 [response to gravity]
GO:0014070 [response to organic cyclic compound]
GO:0031668 [cellular response to extracellular stimulus]
GO:0032570 [response to progesterone]
GO:0034097 [response to cytokine]
GO:0042493 [response to drug]
GO:0042542 [response to hydrogen peroxide]
GO:0042734 [presynaptic membrane]
GO:0043005 [neuron projection]
GO:0043065 [positive regulation of apoptotic process]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043565 [sequence-specific DNA binding]
GO:0045787 [positive regulation of cell cycle]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity]
GO:0051412 [response to corticosterone]
GO:0051591 [response to cAMP]
GO:0060674 [placenta blood vessel development]
GO:2000144 [positive regulation of DNA-templated transcription, initiation]
Show all
271 aa
29.4 kDa
No 0
FOSL1-002
ENSP00000393302
ENST00000448083
P15407 [Direct mapping]
Fos-related antigen 1
Show all
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Basic domains
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0000982 [transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006935 [chemotaxis]
GO:0006968 [cellular defense response]
GO:0008284 [positive regulation of cell proliferation]
GO:0009615 [response to virus]
GO:2000144 [positive regulation of DNA-templated transcription, initiation]
Show all
169 aa
17.6 kDa
No 0
FOSL1-004
ENSP00000434350
ENST00000534222
E9PQT6 [Direct mapping]
Fos-related antigen 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
13 aa
1.4 kDa
No 0
FOSL1-005
ENSP00000436276
ENST00000531493
E9PPX2 [Direct mapping]
Fos-related antigen 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
Show all
235 aa
25 kDa
No 0
FOSL1-006
ENSP00000431594
ENST00000532401
E9PKL5 [Direct mapping]
Fos-related antigen 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
Show all
135 aa
14.2 kDa
No 0

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