Cell atlas - KCNE5 - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

KCNE5

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol

Human cell
	Cytosol

Please wait until image is loaded before changing channels

GENERAL INFORMATION
Gene name	KCNE5
Gene description	Potassium channel, voltage gated subfamily E regulatory beta subunit 5
Protein class	Disease related genes Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	1
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the cytosol.
RNA cell category	Cell line enhanced (HMC-1)
Protein evidence	Evidence at protein level
Main location	Localized to the Cytosol (uncertain)

DATA RELIABILITY
Reliability score	Uncertain based on 1 antibody. HPA042316
	SHOW MORE

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (HMC-1) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the cytosol.

Main location

Cytosol (uncertain)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA042316	A-431	Cytosol
	HPA042316	U-2 OS	Cytosol
	HPA042316	U-251 MG	Cytosol

GENE INFORMATION
Gene name	KCNE5 (HGNC Symbol)
Synonyms	KCNE1L
Description	Potassium channel, voltage gated subfamily E regulatory beta subunit 5 (HGNC Symbol)
Entrez gene summary	Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a membrane protein which has sequence similarity to the KCNE1 gene product, a member of the potassium channel, voltage-gated, isk-related subfamily. This intronless gene is deleted in AMME contiguous gene syndrome and may be involved in the cardiac and neurologic abnormalities found in the AMME contiguous gene syndrome. [provided by RefSeq, Jul 2008]
Chromosome	X
Cytoband	q23
Chromosome location (bp)	109623700 - 109625172
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000176076 (version 83.38)
Entrez gene	23630
UniProt	Q9UJ90 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UJ90
Antibodypedia	KCNE5 antibodies

PROTEIN BROWSER

KCNE5-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
KCNE5-001 ENSP00000361173 ENST00000372101	Q9UJ90 [Direct mapping] Potassium voltage-gated channel subfamily E regulatory beta subunit 5 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Show all	GO:0005249 [voltage-gated potassium channel activity] GO:0008016 [regulation of heart contraction] GO:0008076 [voltage-gated potassium channel complex] GO:0015459 [potassium channel regulator activity] GO:0044325 [ion channel binding] GO:0060048 [cardiac muscle contraction] GO:0060306 [regulation of membrane repolarization] GO:0060307 [regulation of ventricular cardiac muscle cell membrane repolarization] GO:0060372 [regulation of atrial cardiac muscle cell membrane repolarization] GO:0071435 [potassium ion export] GO:0071805 [potassium ion transmembrane transport] GO:0086005 [ventricular cardiac muscle cell action potential] GO:0086008 [voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization] GO:0086013 [membrane repolarization during cardiac muscle cell action potential] GO:0086014 [atrial cardiac muscle cell action potential] GO:0086091 [regulation of heart rate by cardiac conduction] GO:1901379 [regulation of potassium ion transmembrane transport] GO:1901380 [negative regulation of potassium ion transmembrane transport] GO:1901381 [positive regulation of potassium ion transmembrane transport] GO:2001257 [regulation of cation channel activity] Show all	142 aa 15 kDa	No	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.