Expression of MC5R in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Melanocortin 5 receptor

Protein class

G-protein coupled receptors, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA042365

GENE INFORMATION
Gene name	MC5R
Synonyms
Description	Melanocortin 5 receptor (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the seven-pass transmembrane G protein-coupled melanocortin receptor protein family that stimulate cAMP signal transduction. The encoded protein is a receptor for melanocyte-stimulating hormone and adrenocorticotropic hormone and is suggested to play a role in sebum generation. [provided by RefSeq, Jun 2010]
Chromosome	18
Cytoband	p11.21
Chromosome location (bp)	13824155 - 13826743
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000176136 (version 83.38)
Entrez gene	4161
UniProt	P33032 (UniProt - Evidence at protein level)
neXtProt	NX_P33032
Antibodypedia	MC5R antibodies

PROTEIN BROWSER

MC5R-001	MC5R-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MC5R-001 ENSP00000318077 ENST00000324750	P33032 [Direct mapping] Melanocortin receptor 5 Show all	G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0004930 [G-protein coupled receptor activity] GO:0004977 [melanocortin receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007187 [G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger] GO:0016021 [integral component of membrane] GO:0030819 [positive regulation of cAMP biosynthetic process] GO:0042562 [hormone binding] Show all	325 aa 36.6 kDa	No	7
MC5R-002 ENSP00000468086 ENST00000589410	K7ER30 [Direct mapping] Melanocortin receptor 5 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Show all	GO:0004930 [G-protein coupled receptor activity] GO:0004977 [melanocortin receptor activity] GO:0005886 [plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016021 [integral component of membrane] Show all	173 aa 19 kDa	No	4