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GJC3

GENERAL INFORMATION

Gene name

 GJC3

Gene description

 Gap junction protein, gamma 3, 30.2kDa

Protein class

 Predicted membrane proteins
Transporters

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (breast, prostate)
GTEx:Tissue enhanced (salivary gland, breast)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic and membranous expression in several tissues, including breast and CNS.

DATA RELIABILITY

Data reliability
description

 Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
HPA015024
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (breast, prostate)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (salivary gland, breast)

GENE INFORMATION

Gene name

 GJC3 (HGNC Symbol)

Synonyms

 CX30.2, GJE1

Description

 Gap junction protein, gamma 3, 30.2kDa (HGNC Symbol)

Entrez gene summary

 This gene encodes a gap junction protein. The encoded protein, also known as a connexin, plays a role in formation of gap junctions, which provide direct connections between neighboring cells. Mutations in this gene have been reported to be associated with nonsyndromic hearing loss.[provided by RefSeq, Feb 2010]

Chromosome

 7

Cytoband

 q22.1

Chromosome location (bp)

 99923269 - 99929620

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000176402 (version 83.38)

Entrez gene

 349149

UniProt

 Q8NFK1 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q8NFK1

Antibodypedia

 GJC3 antibodies

PROTEIN BROWSER
GJC3-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GJC3-001
ENSP00000325775
ENST00000312891
Q8NFK1 [Direct mapping]
Gap junction gamma-3 protein
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Transporters
   Transporter channels and pores
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
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GO:0005922 [connexon complex]
GO:0007154 [cell communication]
GO:0007605 [sensory perception of sound]
GO:0016021 [integral component of membrane]
GO:0042552 [myelination]
GO:0042803 [protein homodimerization activity]
GO:0043209 [myelin sheath]
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 279 aa
31.3 kDa 		No 3

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.