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Prostate and thyroid cancers along with several melanomas, lung, colorectal, liver, ovarian, pancreatic and stomach cancers exhibited weak to moderate cytoplasmic positivity with a granular pattern. Remaining tumors were generally negative.
GENE INFORMATION
Gene name
CLEC14A (HGNC Symbol)
Synonyms
C14orf27
Description
C-type lectin domain family 14, member A (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. This family member plays a role in cell-cell adhesion and angiogenesis. It functions in filopodia formation, cell migration and tube formation. Due to its presence at higher levels in tumor endothelium than in normal tissue endothelium, it is considered to be a candidate for tumor vascular targeting. [provided by RefSeq, Jan 2012]
