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MEX3C

GENERAL INFORMATION

Gene name

 MEX3C

Gene description

 Mex-3 RNA binding family member C

Protein class

 Disease related genes
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Tissue enriched (testis)
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in several tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Uncertain based on 1 antibody.
HPA040603
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (testis)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 MEX3C (HGNC Symbol)

Synonyms

 FLJ38871, RKHD2, RNF194

Description

 Mex-3 RNA binding family member C (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of a family of proteins with two K homology (KH) RNA-binding domains and a C-terminal RING-finger domain. The protein interacts with mRNA via the KH domains, and the protein shuttles between the nucleus and cytoplasm. Polymorphisms in this gene may contribute to hypertension. [provided by RefSeq, Oct 2009]

Chromosome

 18

Cytoband

 q21.2

Chromosome location (bp)

 51174550 - 51218304

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000176624 (version 83.38)

Entrez gene

 51320

UniProt

 Q5U5Q3 (UniProt - Evidence at protein level)

neXtProt

 NX_Q5U5Q3

Antibodypedia

 MEX3C antibodies

PROTEIN BROWSER
MEX3C-001
MEX3C-002
MEX3C-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MEX3C-001
ENSP00000385610
ENST00000406189
Q5U5Q3 [Direct mapping]
RNA-binding E3 ubiquitin-protein ligase MEX3C
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003415 [chondrocyte hypertrophy]
GO:0003676 [nucleic acid binding]
GO:0003723 [RNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0008270 [zinc ion binding]
GO:0016874 [ligase activity]
GO:0044822 [poly(A) RNA binding]
GO:0045598 [regulation of fat cell differentiation]
GO:0097009 [energy homeostasis]
GO:0098779 [mitophagy in response to mitochondrial depolarization]
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 659 aa
69.4 kDa 		Yes 0
MEX3C-002
ENSP00000468078
ENST00000592416
K7ER23 [Direct mapping]
RNA-binding E3 ubiquitin-protein ligase MEX3C
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 115 aa
12.2 kDa 		No 0
MEX3C-201
ENSP00000482566
ENST00000616921
M9T4I7 [Direct mapping]
MEX3C variant 2; RNA-binding E3 ubiquitin-protein ligase MEX3C
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   Phobius predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0003723 [RNA binding]
GO:0005515 [protein binding]
GO:0008270 [zinc ion binding]
Show all
 489 aa
52.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.