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BDNF

GENERAL INFORMATION

Gene name

 BDNF

Gene description

 Brain-derived neurotrophic factor

Protein class

 Cancer-related genes
Disease related genes
Plasma proteins
Predicted intracellular proteins
Predicted membrane proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Membrane,Secreted

Number of transcripts

 17
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (cerebral cortex)
GTEx:Mixed
FANTOM5:Tissue enhanced (cerebellum)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression mainly in CNS.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Secreted protein, tissue location of RNA and protein might differ and correlation is complex.

Reliability score

 Supported based on 1 antibody.
CAB009564
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Cerebellum

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cerebral cortex)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cerebellum)

GENE INFORMATION

Gene name

 BDNF

Synonyms

Description

 Brain-derived neurotrophic factor (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the nerve growth factor family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protein. Binding of this protein to its cognate receptor promotes neuronal survival in the adult brain. Expression of this gene is reduced in Alzheimer's, Parkinson's, and Huntington's disease patients. This gene may play a role in the regulation of the stress response and in the biology of mood disorders. [provided by RefSeq, Nov 2015]

Chromosome

 11

Cytoband

 p14.1

Chromosome location (bp)

 27654893 - 27722058

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000176697 (version 83.38)

Entrez gene

 627

UniProt

 P23560 (UniProt - Evidence at protein level)

neXtProt

 NX_P23560

Antibodypedia

 BDNF antibodies

PROTEIN BROWSER
«
BDNF-001
BDNF-002
BDNF-003
BDNF-004
BDNF-007
BDNF-008
BDNF-009
BDNF-010
BDNF-011
BDNF-012
BDNF-013
BDNF-014
BDNF-015
BDNF-016
BDNF-018
BDNF-201
BDNF-202
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
BDNF-001
ENSP00000432035
ENST00000525950
P23560 [Direct mapping]
Brain-derived neurotrophic factor
A0A0E3SU01 [Target identity:100%; Query identity:100%]
Brain-derived neurotrophic factor
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Protein evidence (Kim et al 2014)
Show all
GO:0005102 [receptor binding]
GO:0005169 [neurotrophin TRKB receptor binding]
GO:0005737 [cytoplasm]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007267 [cell-cell signaling]
GO:0007399 [nervous system development]
GO:0007411 [axon guidance]
GO:0007416 [synapse assembly]
GO:0008083 [growth factor activity]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0031547 [brain-derived neurotrophic factor receptor signaling pathway]
GO:0031550 [positive regulation of brain-derived neurotrophic factor receptor signaling pathway]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0045664 [regulation of neuron differentiation]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048668 [collateral sprouting]
GO:0048672 [positive regulation of collateral sprouting]
GO:0048812 [neuron projection morphogenesis]
GO:0051965 [positive regulation of synapse assembly]
Show all
 247 aa
27.8 kDa 		Yes 0
BDNF-002
ENSP00000379305
ENST00000395981
P23560 [Direct mapping]
Brain-derived neurotrophic factor
A0A0E3SU01 [Target identity:100%; Query identity:100%]
Brain-derived neurotrophic factor
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Protein evidence (Kim et al 2014)
Show all
GO:0005102 [receptor binding]
GO:0005169 [neurotrophin TRKB receptor binding]
GO:0005737 [cytoplasm]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007267 [cell-cell signaling]
GO:0007399 [nervous system development]
GO:0007411 [axon guidance]
GO:0007416 [synapse assembly]
GO:0008083 [growth factor activity]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0031547 [brain-derived neurotrophic factor receptor signaling pathway]
GO:0031550 [positive regulation of brain-derived neurotrophic factor receptor signaling pathway]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0045664 [regulation of neuron differentiation]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048668 [collateral sprouting]
GO:0048672 [positive regulation of collateral sprouting]
GO:0048812 [neuron projection morphogenesis]
GO:0051965 [positive regulation of synapse assembly]
Show all
 247 aa
27.8 kDa 		Yes 0
BDNF-003
ENSP00000379302
ENST00000395978
P23560 [Direct mapping]
Brain-derived neurotrophic factor
A0A0E3SU01 [Target identity:100%; Query identity:100%]
Brain-derived neurotrophic factor
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Protein evidence (Kim et al 2014)
Show all
GO:0005102 [receptor binding]
GO:0005169 [neurotrophin TRKB receptor binding]
GO:0005737 [cytoplasm]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007267 [cell-cell signaling]
GO:0007399 [nervous system development]
GO:0007411 [axon guidance]
GO:0007416 [synapse assembly]
GO:0008083 [growth factor activity]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0031547 [brain-derived neurotrophic factor receptor signaling pathway]
GO:0031550 [positive regulation of brain-derived neurotrophic factor receptor signaling pathway]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0045664 [regulation of neuron differentiation]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048668 [collateral sprouting]
GO:0048672 [positive regulation of collateral sprouting]
GO:0048812 [neuron projection morphogenesis]
GO:0051965 [positive regulation of synapse assembly]
Show all
 247 aa
27.8 kDa 		Yes 0
BDNF-004
ENSP00000435805
ENST00000532997
P23560 [Direct mapping]
Brain-derived neurotrophic factor
A0A0E3SU01 [Target identity:100%; Query identity:100%]
Brain-derived neurotrophic factor
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Protein evidence (Kim et al 2014)
Show all
GO:0005102 [receptor binding]
GO:0005169 [neurotrophin TRKB receptor binding]
GO:0005737 [cytoplasm]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007267 [cell-cell signaling]
GO:0007399 [nervous system development]
GO:0007411 [axon guidance]
GO:0007416 [synapse assembly]
GO:0008083 [growth factor activity]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0031547 [brain-derived neurotrophic factor receptor signaling pathway]
GO:0031550 [positive regulation of brain-derived neurotrophic factor receptor signaling pathway]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0045664 [regulation of neuron differentiation]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048668 [collateral sprouting]
GO:0048672 [positive regulation of collateral sprouting]
GO:0048812 [neuron projection morphogenesis]
GO:0051965 [positive regulation of synapse assembly]
Show all
 247 aa
27.8 kDa 		Yes 0
BDNF-007
ENSP00000379307
ENST00000395983
P23560 [Direct mapping]
Brain-derived neurotrophic factor
A0A0E3SU01 [Target identity:100%; Query identity:100%]
Brain-derived neurotrophic factor
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Protein evidence (Kim et al 2014)
Show all
GO:0005102 [receptor binding]
GO:0005169 [neurotrophin TRKB receptor binding]
GO:0005737 [cytoplasm]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007267 [cell-cell signaling]
GO:0007399 [nervous system development]
GO:0007411 [axon guidance]
GO:0007416 [synapse assembly]
GO:0008083 [growth factor activity]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0031547 [brain-derived neurotrophic factor receptor signaling pathway]
GO:0031550 [positive regulation of brain-derived neurotrophic factor receptor signaling pathway]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0045664 [regulation of neuron differentiation]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048668 [collateral sprouting]
GO:0048672 [positive regulation of collateral sprouting]
GO:0048812 [neuron projection morphogenesis]
GO:0051965 [positive regulation of synapse assembly]
Show all
 247 aa
27.8 kDa 		Yes 0
BDNF-008
ENSP00000414303
ENST00000438929
P23560 [Direct mapping]
Brain-derived neurotrophic factor
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Protein evidence (Kim et al 2014)
Show all
GO:0001657 [ureteric bud development]
GO:0001662 [behavioral fear response]
GO:0005102 [receptor binding]
GO:0005169 [neurotrophin TRKB receptor binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007214 [gamma-aminobutyric acid signaling pathway]
GO:0007267 [cell-cell signaling]
GO:0007399 [nervous system development]
GO:0007406 [negative regulation of neuroblast proliferation]
GO:0007411 [axon guidance]
GO:0007412 [axon target recognition]
GO:0007416 [synapse assembly]
GO:0007611 [learning or memory]
GO:0007631 [feeding behavior]
GO:0008038 [neuron recognition]
GO:0008083 [growth factor activity]
GO:0014047 [glutamate secretion]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0016358 [dendrite development]
GO:0019222 [regulation of metabolic process]
GO:0021675 [nerve development]
GO:0031547 [brain-derived neurotrophic factor receptor signaling pathway]
GO:0031550 [positive regulation of brain-derived neurotrophic factor receptor signaling pathway]
GO:0032229 [negative regulation of synaptic transmission, GABAergic]
GO:0042490 [mechanoreceptor differentiation]
GO:0042493 [response to drug]
GO:0042596 [fear response]
GO:0043066 [negative regulation of apoptotic process]
GO:0043523 [regulation of neuron apoptotic process]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0045664 [regulation of neuron differentiation]
GO:0045666 [positive regulation of neuron differentiation]
GO:0046668 [regulation of retinal cell programmed cell death]
GO:0048167 [regulation of synaptic plasticity]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048668 [collateral sprouting]
GO:0048672 [positive regulation of collateral sprouting]
GO:0048675 [axon extension]
GO:0048812 [neuron projection morphogenesis]
GO:0048839 [inner ear development]
GO:0051965 [positive regulation of synapse assembly]
GO:0060080 [inhibitory postsynaptic potential]
GO:0060548 [negative regulation of cell death]
GO:0061193 [taste bud development]
GO:0097484 [dendrite extension]
Show all
 329 aa
37.1 kDa 		No 1
BDNF-009
ENSP00000435564
ENST00000530861
P23560 [Direct mapping]
Brain-derived neurotrophic factor
A0A0E3SU01 [Target identity:100%; Query identity:100%]
Brain-derived neurotrophic factor
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Protein evidence (Kim et al 2014)
Show all
GO:0005102 [receptor binding]
GO:0005169 [neurotrophin TRKB receptor binding]
GO:0005737 [cytoplasm]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007267 [cell-cell signaling]
GO:0007399 [nervous system development]
GO:0007411 [axon guidance]
GO:0007416 [synapse assembly]
GO:0008083 [growth factor activity]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0031547 [brain-derived neurotrophic factor receptor signaling pathway]
GO:0031550 [positive regulation of brain-derived neurotrophic factor receptor signaling pathway]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0045664 [regulation of neuron differentiation]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048668 [collateral sprouting]
GO:0048672 [positive regulation of collateral sprouting]
GO:0048812 [neuron projection morphogenesis]
GO:0051965 [positive regulation of synapse assembly]
Show all
 247 aa
27.8 kDa 		Yes 0
BDNF-010
ENSP00000349084
ENST00000356660
P23560 [Direct mapping]
Brain-derived neurotrophic factor
A0A0E3SU01 [Target identity:100%; Query identity:100%]
Brain-derived neurotrophic factor
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Protein evidence (Kim et al 2014)
Show all
GO:0005102 [receptor binding]
GO:0005169 [neurotrophin TRKB receptor binding]
GO:0005737 [cytoplasm]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007267 [cell-cell signaling]
GO:0007399 [nervous system development]
GO:0007411 [axon guidance]
GO:0007416 [synapse assembly]
GO:0008083 [growth factor activity]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0031547 [brain-derived neurotrophic factor receptor signaling pathway]
GO:0031550 [positive regulation of brain-derived neurotrophic factor receptor signaling pathway]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0045664 [regulation of neuron differentiation]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048668 [collateral sprouting]
GO:0048672 [positive regulation of collateral sprouting]
GO:0048812 [neuron projection morphogenesis]
GO:0051965 [positive regulation of synapse assembly]
Show all
 247 aa
27.8 kDa 		Yes 0
BDNF-011
ENSP00000400502
ENST00000418212
P23560 [Direct mapping]
Brain-derived neurotrophic factor
A0A0E3SU01 [Target identity:100%; Query identity:100%]
Brain-derived neurotrophic factor
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Protein evidence (Kim et al 2014)
Show all
GO:0005102 [receptor binding]
GO:0005169 [neurotrophin TRKB receptor binding]
GO:0005737 [cytoplasm]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007267 [cell-cell signaling]
GO:0007399 [nervous system development]
GO:0007411 [axon guidance]
GO:0007416 [synapse assembly]
GO:0008083 [growth factor activity]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0031547 [brain-derived neurotrophic factor receptor signaling pathway]
GO:0031550 [positive regulation of brain-derived neurotrophic factor receptor signaling pathway]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0045664 [regulation of neuron differentiation]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048668 [collateral sprouting]
GO:0048672 [positive regulation of collateral sprouting]
GO:0048812 [neuron projection morphogenesis]
GO:0051965 [positive regulation of synapse assembly]
Show all
 247 aa
27.8 kDa 		Yes 0
BDNF-012
ENSP00000432376
ENST00000533246
P23560 [Direct mapping]
Brain-derived neurotrophic factor
A0A0E3SU01 [Target identity:100%; Query identity:100%]
Brain-derived neurotrophic factor
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Protein evidence (Kim et al 2014)
Show all
GO:0005102 [receptor binding]
GO:0005169 [neurotrophin TRKB receptor binding]
GO:0005737 [cytoplasm]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007267 [cell-cell signaling]
GO:0007399 [nervous system development]
GO:0007411 [axon guidance]
GO:0007416 [synapse assembly]
GO:0008083 [growth factor activity]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0031547 [brain-derived neurotrophic factor receptor signaling pathway]
GO:0031550 [positive regulation of brain-derived neurotrophic factor receptor signaling pathway]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0045664 [regulation of neuron differentiation]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048668 [collateral sprouting]
GO:0048672 [positive regulation of collateral sprouting]
GO:0048812 [neuron projection morphogenesis]
GO:0051965 [positive regulation of synapse assembly]
Show all
 247 aa
27.8 kDa 		Yes 0
BDNF-013
ENSP00000379309
ENST00000395986
P23560 [Direct mapping]
Brain-derived neurotrophic factor
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Protein evidence (Kim et al 2014)
Show all
GO:0005102 [receptor binding]
GO:0005169 [neurotrophin TRKB receptor binding]
GO:0005737 [cytoplasm]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007267 [cell-cell signaling]
GO:0007399 [nervous system development]
GO:0007411 [axon guidance]
GO:0007416 [synapse assembly]
GO:0008083 [growth factor activity]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0031547 [brain-derived neurotrophic factor receptor signaling pathway]
GO:0031550 [positive regulation of brain-derived neurotrophic factor receptor signaling pathway]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0045664 [regulation of neuron differentiation]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048668 [collateral sprouting]
GO:0048672 [positive regulation of collateral sprouting]
GO:0048812 [neuron projection morphogenesis]
GO:0051965 [positive regulation of synapse assembly]
Show all
 262 aa
29.8 kDa 		No 0
BDNF-014
ENSP00000432727
ENST00000533131
P23560 [Direct mapping]
Brain-derived neurotrophic factor
A0A0E3SU01 [Target identity:100%; Query identity:100%]
Brain-derived neurotrophic factor
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Show all
GO:0005102 [receptor binding]
GO:0005169 [neurotrophin TRKB receptor binding]
GO:0005737 [cytoplasm]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007267 [cell-cell signaling]
GO:0007399 [nervous system development]
GO:0007411 [axon guidance]
GO:0007416 [synapse assembly]
GO:0008083 [growth factor activity]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0031547 [brain-derived neurotrophic factor receptor signaling pathway]
GO:0031550 [positive regulation of brain-derived neurotrophic factor receptor signaling pathway]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0045664 [regulation of neuron differentiation]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048668 [collateral sprouting]
GO:0048672 [positive regulation of collateral sprouting]
GO:0048812 [neuron projection morphogenesis]
GO:0051965 [positive regulation of synapse assembly]
Show all
 247 aa
27.8 kDa 		Yes 0
BDNF-015
ENSP00000389345
ENST00000439476
P23560 [Direct mapping]
Brain-derived neurotrophic factor
A0A0E3SU01 [Target identity:100%; Query identity:100%]
Brain-derived neurotrophic factor
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Protein evidence (Kim et al 2014)
Show all
GO:0005102 [receptor binding]
GO:0005169 [neurotrophin TRKB receptor binding]
GO:0005737 [cytoplasm]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007267 [cell-cell signaling]
GO:0007399 [nervous system development]
GO:0007411 [axon guidance]
GO:0007416 [synapse assembly]
GO:0008083 [growth factor activity]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0031547 [brain-derived neurotrophic factor receptor signaling pathway]
GO:0031550 [positive regulation of brain-derived neurotrophic factor receptor signaling pathway]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0045664 [regulation of neuron differentiation]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048668 [collateral sprouting]
GO:0048672 [positive regulation of collateral sprouting]
GO:0048812 [neuron projection morphogenesis]
GO:0051965 [positive regulation of synapse assembly]
Show all
 247 aa
27.8 kDa 		Yes 0
BDNF-016
ENSP00000437138
ENST00000525528
P23560 [Direct mapping]
Brain-derived neurotrophic factor
A0A0E3SU01 [Target identity:100%; Query identity:100%]
Brain-derived neurotrophic factor
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Protein evidence (Kim et al 2014)
Show all
GO:0005102 [receptor binding]
GO:0005169 [neurotrophin TRKB receptor binding]
GO:0005737 [cytoplasm]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007267 [cell-cell signaling]
GO:0007399 [nervous system development]
GO:0007411 [axon guidance]
GO:0007416 [synapse assembly]
GO:0008083 [growth factor activity]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0031547 [brain-derived neurotrophic factor receptor signaling pathway]
GO:0031550 [positive regulation of brain-derived neurotrophic factor receptor signaling pathway]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0045664 [regulation of neuron differentiation]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048668 [collateral sprouting]
GO:0048672 [positive regulation of collateral sprouting]
GO:0048812 [neuron projection morphogenesis]
GO:0051965 [positive regulation of synapse assembly]
Show all
 247 aa
27.8 kDa 		Yes 0
BDNF-018
ENSP00000320002
ENST00000314915
P23560 [Direct mapping]
Brain-derived neurotrophic factor
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Protein evidence (Kim et al 2014)
Show all
GO:0005102 [receptor binding]
GO:0005169 [neurotrophin TRKB receptor binding]
GO:0005737 [cytoplasm]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007267 [cell-cell signaling]
GO:0007399 [nervous system development]
GO:0007411 [axon guidance]
GO:0007416 [synapse assembly]
GO:0008083 [growth factor activity]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0031547 [brain-derived neurotrophic factor receptor signaling pathway]
GO:0031550 [positive regulation of brain-derived neurotrophic factor receptor signaling pathway]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0045664 [regulation of neuron differentiation]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048668 [collateral sprouting]
GO:0048672 [positive regulation of collateral sprouting]
GO:0048812 [neuron projection morphogenesis]
GO:0051965 [positive regulation of synapse assembly]
Show all
 255 aa
28.9 kDa 		Yes 0
BDNF-201
ENSP00000379304
ENST00000395980
P23560 [Direct mapping]
Brain-derived neurotrophic factor
A0A0E3SU01 [Target identity:100%; Query identity:100%]
Brain-derived neurotrophic factor
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Protein evidence (Kim et al 2014)
Show all
GO:0005102 [receptor binding]
GO:0005169 [neurotrophin TRKB receptor binding]
GO:0005737 [cytoplasm]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007267 [cell-cell signaling]
GO:0007399 [nervous system development]
GO:0007411 [axon guidance]
GO:0007416 [synapse assembly]
GO:0008083 [growth factor activity]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0031547 [brain-derived neurotrophic factor receptor signaling pathway]
GO:0031550 [positive regulation of brain-derived neurotrophic factor receptor signaling pathway]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0045664 [regulation of neuron differentiation]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048668 [collateral sprouting]
GO:0048672 [positive regulation of collateral sprouting]
GO:0048812 [neuron projection morphogenesis]
GO:0051965 [positive regulation of synapse assembly]
Show all
 247 aa
27.8 kDa 		Yes 0
BDNF-202
ENSP00000389564
ENST00000420794
P23560 [Direct mapping]
Brain-derived neurotrophic factor
A0A0E3SU01 [Target identity:100%; Query identity:100%]
Brain-derived neurotrophic factor
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Protein evidence (Kim et al 2014)
Show all
GO:0005102 [receptor binding]
GO:0005169 [neurotrophin TRKB receptor binding]
GO:0005737 [cytoplasm]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007267 [cell-cell signaling]
GO:0007399 [nervous system development]
GO:0007411 [axon guidance]
GO:0007416 [synapse assembly]
GO:0008083 [growth factor activity]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0031547 [brain-derived neurotrophic factor receptor signaling pathway]
GO:0031550 [positive regulation of brain-derived neurotrophic factor receptor signaling pathway]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0045664 [regulation of neuron differentiation]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048668 [collateral sprouting]
GO:0048672 [positive regulation of collateral sprouting]
GO:0048812 [neuron projection morphogenesis]
GO:0051965 [positive regulation of synapse assembly]
Show all
 247 aa
27.8 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.