Tissue expression of ACSF3 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	ACSF3
Gene description	Acyl-CoA synthetase family member 3
Protein class	Disease related genes Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	12
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	ACSF3
Synonyms
Description	Acyl-CoA synthetase family member 3 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the acyl-CoA synthetase family of enzymes that activate fatty acids by catalyzing the formation of a thioester linkage between fatty acids and coenzyme A. The encoded protein is localized to mitochondria, has high specificity for malonate and methylmalonate and possesses malonyl-CoA synthetase activity. Mutations in this gene are a cause of combined malonic and methylmalonic aciduria. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Sep 2013]
Chromosome	16
Cytoband	q24.3
Chromosome location (bp)	89088375 - 89155846
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000176715 (version 83.38)
Entrez gene	197322
UniProt	Q4G176 (UniProt - Evidence at protein level)
neXtProt	NX_Q4G176
Antibodypedia	ACSF3 antibodies

PROTEIN BROWSER

ACSF3-001	ACSF3-002	ACSF3-003	ACSF3-009	ACSF3-010	ACSF3-011	ACSF3-012	ACSF3-013	ACSF3-014	ACSF3-015	ACSF3-023	ACSF3-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ACSF3-001 ENSP00000320646 ENST00000317447	Q4G176 [Direct mapping] Acyl-CoA synthetase family member 3, mitochondrial Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0005524 [ATP binding] GO:0005739 [mitochondrion] GO:0005759 [mitochondrial matrix] GO:0006631 [fatty acid metabolic process] GO:0006633 [fatty acid biosynthetic process] GO:0008152 [metabolic process] GO:0016878 [acid-thiol ligase activity] GO:0019432 [triglyceride biosynthetic process] GO:0035338 [long-chain fatty-acyl-CoA biosynthetic process] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] GO:0090409 [malonyl-CoA synthetase activity] GO:0090410 [malonate catabolic process] Show all	576 aa 64.1 kDa	No	1
ACSF3-002 ENSP00000367596 ENST00000378345	F5H5A1 [Direct mapping] Acyl-CoA synthetase family member 3, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0008152 [metabolic process] Show all	311 aa 35.1 kDa	No	0
ACSF3-003 ENSP00000384627 ENST00000406948	Q4G176 [Direct mapping] Acyl-CoA synthetase family member 3, mitochondrial Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0005524 [ATP binding] GO:0005739 [mitochondrion] GO:0005759 [mitochondrial matrix] GO:0006631 [fatty acid metabolic process] GO:0006633 [fatty acid biosynthetic process] GO:0008152 [metabolic process] GO:0016878 [acid-thiol ligase activity] GO:0019432 [triglyceride biosynthetic process] GO:0035338 [long-chain fatty-acyl-CoA biosynthetic process] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] GO:0090409 [malonyl-CoA synthetase activity] GO:0090410 [malonate catabolic process] Show all	576 aa 64.1 kDa	No	1
ACSF3-009 ENSP00000440734 ENST00000537290	F5GX20 [Direct mapping] Acyl-CoA synthetase family member 3, mitochondrial Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0008152 [metabolic process] Show all	237 aa 26 kDa	No	0
ACSF3-010 ENSP00000445397 ENST00000540697	F5H362 [Direct mapping] Acyl-CoA synthetase family member 3, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0008152 [metabolic process] Show all	190 aa 21.5 kDa	No	0
ACSF3-011 ENSP00000439201 ENST00000537895	F5H3B2 [Direct mapping] Acyl-CoA synthetase family member 3, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0008152 [metabolic process] Show all	106 aa 12.2 kDa	No	0
ACSF3-012 ENSP00000442781 ENST00000544543	F5H755 [Direct mapping] Acyl-CoA synthetase family member 3, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0008152 [metabolic process] Show all	235 aa 26.6 kDa	No	0
ACSF3-013 ENSP00000443428 ENST00000535176	H0YGJ0 [Direct mapping] Acyl-CoA synthetase family member 3, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		106 aa 12 kDa	No	0
ACSF3-014 ENSP00000442683 ENST00000543676	H0YGC7 [Direct mapping] Acyl-CoA synthetase family member 3, mitochondrial Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0008152 [metabolic process] Show all	183 aa 20.3 kDa	No	0
ACSF3-015 ENSP00000445870 ENST00000538340	H0YH37 [Direct mapping] Acyl-CoA synthetase family member 3, mitochondrial Show all	THUMBUP predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0008152 [metabolic process] Show all	144 aa 16.7 kDa	No	0
ACSF3-023 ENSP00000457301 ENST00000541755	H3BTS0 [Direct mapping] Acyl-CoA synthetase family member 3, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		28 aa 3.1 kDa	No	0
ACSF3-201 ENSP00000479130 ENST00000614302	Q4G176 [Direct mapping] Acyl-CoA synthetase family member 3, mitochondrial Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0005524 [ATP binding] GO:0005739 [mitochondrion] GO:0005759 [mitochondrial matrix] GO:0006631 [fatty acid metabolic process] GO:0006633 [fatty acid biosynthetic process] GO:0008152 [metabolic process] GO:0016878 [acid-thiol ligase activity] GO:0019432 [triglyceride biosynthetic process] GO:0035338 [long-chain fatty-acyl-CoA biosynthetic process] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] GO:0090409 [malonyl-CoA synthetase activity] GO:0090410 [malonate catabolic process] Show all	576 aa 64.1 kDa	No	1