Cell atlas - IRX5 - The Human Protein Atlas

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IRX5

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Microtubules
	Nuclear speckles

Human cell
	Cytosol
	Microtubules
	Nucleoplasm

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GENERAL INFORMATION
Gene name	IRX5
Gene description	Iroquois homeobox 5
Protein class	Disease related genes Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nuclear speckles. In addition localized to the cytosol & microtubules.
RNA cell category	Cell line enhanced (T-47d)
Protein evidence	Evidence at protein level
Main location	Localized to the Nuclear speckles (approved)
Additional location	In addition localized to the Microtubules (approved), Cytosol (approved)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA047130
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (T-47d) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nuclear speckles. In addition localized to the cytosol & microtubules.

Main location

Nuclear speckles (approved)

Additional location

Microtubules (approved), Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA047130	HaCaT	Nuclear speckles
	HPA047130	HaCaT	Cytosol
	HPA047130	MCF7	Nuclear speckles
			Microtubules	Intensity
			Cytosol
	HPA047130	U-2 OS	Nuclear speckles
	HPA047130	U-2 OS	Microtubules

GENE INFORMATION
Gene name	IRX5 (HGNC Symbol)
Synonyms	IRX-2a
Description	Iroquois homeobox 5 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the iroquois homeobox gene family, which are involved in several embryonic developmental processes. Knockout mice lacking this gene show that it is required for retinal cone bipolar cell differentiation, and that it negatively regulates potassium channel gene expression in the heart to ensure coordinated cardiac repolarization. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
Chromosome	16
Cytoband	q12.2
Chromosome location (bp)	54930862 - 54934485
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000176842 (version 83.38)
Entrez gene	10265
UniProt	P78411 (UniProt - Evidence at protein level)
neXtProt	NX_P78411
Antibodypedia	IRX5 antibodies

PROTEIN BROWSER

IRX5-001	IRX5-002	IRX5-003	IRX5-004	IRX5-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
IRX5-001 ENSP00000378132 ENST00000394636	P78411 [Direct mapping] Iroquois-class homeodomain protein IRX-5 Show all	Predicted intracellular proteins Transcription factors Helix-turn-helix domains Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0002027 [regulation of heart rate] GO:0003677 [DNA binding] GO:0005499 [vitamin D binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0007601 [visual perception] GO:0008406 [gonad development] GO:0010468 [regulation of gene expression] GO:0042551 [neuron maturation] GO:0043565 [sequence-specific DNA binding] GO:0048468 [cell development] GO:0048701 [embryonic cranial skeleton morphogenesis] GO:0050896 [response to stimulus] GO:0060040 [retinal bipolar neuron differentiation] Show all	483 aa 50.4 kDa	No	0
IRX5-002 ENSP00000316250 ENST00000320990	P78411 [Direct mapping] Iroquois-class homeodomain protein IRX-5 Show all	Predicted intracellular proteins Transcription factors Helix-turn-helix domains Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0005499 [vitamin D binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0007601 [visual perception] GO:0008406 [gonad development] GO:0043565 [sequence-specific DNA binding] GO:0048701 [embryonic cranial skeleton morphogenesis] GO:0050896 [response to stimulus] Show all	482 aa 50.3 kDa	No	0
IRX5-003 ENSP00000453660 ENST00000560154	H0YML8 [Direct mapping] Iroquois-class homeodomain protein IRX-5 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		263 aa 27.2 kDa	No	0
IRX5-004 ENSP00000453725 ENST00000558597	P78411 [Direct mapping] Iroquois-class homeodomain protein IRX-5 Show all	Predicted intracellular proteins Transcription factors Helix-turn-helix domains Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0005499 [vitamin D binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0007601 [visual perception] GO:0008406 [gonad development] GO:0043565 [sequence-specific DNA binding] GO:0048701 [embryonic cranial skeleton morphogenesis] GO:0050896 [response to stimulus] Show all	417 aa 43.7 kDa	No	0
IRX5-201 ENSP00000483446 ENST00000620085	A2RRB5 [Direct mapping] IRX5 protein; Iroquois-class homeodomain protein IRX-5 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		146 aa 15.1 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.