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Moderate to strong nuclear staining was displayed mainly in malignant gliomas, breast and skin cancers. Colorectal cancers showed cytoplasmic positivity. Remaining malignanices were weakly stained or negative.
Two cases of non-hodgkin lymphomas displayed moderate nuclear staining. Cancer cells in general were negative. Several malignant melanomas showed cytoplasmic positivity. A few cases of other cancers displayed weak to moderate cytoplasmic or nuclear staining.
Most cancers were negative. Endometrial cancers and gliomas displayed a differential nuclear staining pattern. Two cases of lymphomas displayed moderate nuclear positivity in a majority of cells.
GENE INFORMATION
Gene name
SOX11
Synonyms
Description
SRY (sex determining region Y)-box 11 (HGNC Symbol)
Entrez gene summary
This intronless gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. The protein may function in the developing nervous system and play a role in tumorigenesis. [provided by RefSeq, Jul 2008]
Predicted intracellular proteins Transcription factors Other all-alpha-helical DNA-binding domains Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000976 [transcription regulatory region sequence-specific DNA binding] GO:0000979 [RNA polymerase II core promoter sequence-specific DNA binding] GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0001105 [RNA polymerase II transcription coactivator activity] GO:0001158 [enhancer sequence-specific DNA binding] GO:0001501 [skeletal system development] GO:0001822 [kidney development] GO:0001841 [neural tube formation] GO:0002089 [lens morphogenesis in camera-type eye] GO:0003151 [outflow tract morphogenesis] GO:0003211 [cardiac ventricle formation] GO:0003357 [noradrenergic neuron differentiation] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006366 [transcription from RNA polymerase II promoter] GO:0006412 [translation] GO:0008135 [translation factor activity, RNA binding] GO:0008283 [cell proliferation] GO:0008284 [positive regulation of cell proliferation] GO:0010628 [positive regulation of gene expression] GO:0010629 [negative regulation of gene expression] GO:0014003 [oligodendrocyte development] GO:0014009 [glial cell proliferation] GO:0014032 [neural crest cell development] GO:0017015 [regulation of transforming growth factor beta receptor signaling pathway] GO:0021510 [spinal cord development] GO:0021782 [glial cell development] GO:0030182 [neuron differentiation] GO:0030513 [positive regulation of BMP signaling pathway] GO:0035332 [positive regulation of hippo signaling] GO:0035914 [skeletal muscle cell differentiation] GO:0045666 [positive regulation of neuron differentiation] GO:0045669 [positive regulation of osteoblast differentiation] GO:0045778 [positive regulation of ossification] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046887 [positive regulation of hormone secretion] GO:0048485 [sympathetic nervous system development] GO:0048557 [embryonic digestive tract morphogenesis] GO:0048704 [embryonic skeletal system morphogenesis] GO:0050672 [negative regulation of lymphocyte proliferation] GO:0050769 [positive regulation of neurogenesis] GO:0060022 [hard palate development] GO:0060023 [soft palate development] GO:0060174 [limb bud formation] GO:0060253 [negative regulation of glial cell proliferation] GO:0060412 [ventricular septum morphogenesis] GO:0060425 [lung morphogenesis] GO:0060548 [negative regulation of cell death] GO:0060563 [neuroepithelial cell differentiation] GO:0061029 [eyelid development in camera-type eye] GO:0061053 [somite development] GO:0061303 [cornea development in camera-type eye] GO:0061386 [closure of optic fissure] GO:0072395 [signal transduction involved in cell cycle checkpoint] GO:2000648 [positive regulation of stem cell proliferation] GO:2000678 [negative regulation of transcription regulatory region DNA binding] GO:2001111 [positive regulation of lens epithelial cell proliferation]