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C8orf4

CANCER ATLAS

Gene description

 Chromosome 8 open reading frame 4

Protein class

 Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA027188

GENE INFORMATION

Gene name

 C8orf4 (HGNC Symbol)

Synonyms

 hTC-1, TC-1

Description

 Chromosome 8 open reading frame 4 (HGNC Symbol)

Entrez gene summary

 This gene encodes a small, monomeric, predominantly unstructured protein that functions as a positive regulator of the Wnt/beta-catenin signaling pathway. This protein interacts with a repressor of beta-catenin mediated transcription at nuclear speckles. It is thought to competitively block interactions of the repressor with beta-catenin, resulting in up-regulation of beta-catenin target genes. The encoded protein may also play a role in the NF-kappaB and ERK1/2 signaling pathways. Expression of this gene may play a role in the proliferation of several types of cancer including thyroid cancer, breast cancer and hematological malignancies. [provided by RefSeq, Nov 2011]

Chromosome

 8

Cytoband

 p11.21

Chromosome location (bp)

 40153455 - 40155308

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000176907 (version 83.38)

Entrez gene

 56892

UniProt

 Q9NR00 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NR00

Antibodypedia

 C8orf4 antibodies

PROTEIN BROWSER
C8orf4-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
C8orf4-001
ENSP00000319914
ENST00000315792
Q9NR00 [Direct mapping]
Protein C8orf4
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Show all
GO:0002264 [endothelial cell activation involved in immune response]
GO:0005112 [Notch binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006915 [apoptotic process]
GO:0016607 [nuclear speck]
GO:0034605 [cellular response to heat]
GO:0042346 [positive regulation of NF-kappaB import into nucleus]
GO:0043620 [regulation of DNA-templated transcription in response to stress]
GO:0045746 [negative regulation of Notch signaling pathway]
GO:1902806 [regulation of cell cycle G1/S phase transition]
GO:1903706 [regulation of hemopoiesis]
Show all
 106 aa
12.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.