Cell atlas - C8G - The Human Protein Atlas

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C8G

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Endoplasmic reticulum

Human cell
	Endoplasmic Reticulum

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GENERAL INFORMATION
Gene name	C8G
Gene description	Complement component 8, gamma polypeptide
Protein class	Plasma proteins Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the endoplasmic reticulum.
RNA cell category	Cell line enriched (HMC-1)
Protein evidence	Evidence at protein level
Main location	Localized to the Endoplasmic reticulum (uncertain)

DATA RELIABILITY
Reliability score	Uncertain based on 1 antibody. HPA046269
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enriched (HMC-1) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the endoplasmic reticulum.

Main location

Endoplasmic reticulum (uncertain)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA046269	BJ	Endoplasmic reticulum
	HPA046269	U-2 OS	Endoplasmic reticulum

GENE INFORMATION
Gene name	C8G
Synonyms
Description	Complement component 8, gamma polypeptide (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene belongs to the lipocalin family. It is one of the three subunits that constitutes complement component 8 (C8), which is composed of a disulfide-linked C8 alpha-gamma heterodimer and a non-covalently associated C8 beta chain. C8 participates in the formation of the membrane attack complex (MAC) on bacterial cell membranes. While subunits alpha and beta play a role in complement-mediated bacterial killing, the gamma subunit is not required for the bactericidal activity. [provided by RefSeq, Jul 2011]
Chromosome	9
Cytoband	q34.3
Chromosome location (bp)	136945246 - 136946974
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000176919 (version 83.38)
Entrez gene	733
UniProt	P07360 (UniProt - Evidence at protein level)
neXtProt	NX_P07360
Antibodypedia	C8G antibodies

PROTEIN BROWSER

C8G-003	C8G-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
C8G-003 ENSP00000360697 ENST00000371634	Q5SQ08 [Direct mapping] Complement component C8 gamma chain Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		164 aa 17.6 kDa	Yes	0
C8G-004 ENSP00000224181 ENST00000224181	P07360 [Direct mapping] Complement component C8 gamma chain Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001848 [complement binding] GO:0005576 [extracellular region] GO:0005579 [membrane attack complex] GO:0005615 [extracellular space] GO:0006957 [complement activation, alternative pathway] GO:0006958 [complement activation, classical pathway] GO:0019835 [cytolysis] GO:0019841 [retinol binding] GO:0030449 [regulation of complement activation] GO:0032403 [protein complex binding] GO:0045087 [innate immune response] GO:0070062 [extracellular exosome] GO:0072562 [blood microparticle] Show all	202 aa 22.3 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.