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SHMT1

CANCER ATLAS

Gene description

 Serine hydroxymethyltransferase 1 (soluble)

Protein class

 Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Renal cancer

STAINING SUMMARY
HPA023314

GENE INFORMATION

Gene name

 SHMT1 (HGNC Symbol)

Synonyms

 CSHMT, MGC15229, MGC24556, SHMT

Description

 Serine hydroxymethyltransferase 1 (soluble) (HGNC Symbol)

Entrez gene summary

 This gene encodes the cytosolic form of serine hydroxymethyltransferase, a pyridoxal phosphate-containing enzyme that catalyzes the reversible conversion of serine and tetrahydrofolate to glycine and 5,10-methylene tetrahydrofolate. This reaction provides one-carbon units for synthesis of methionine, thymidylate, and purines in the cytoplasm. This gene is located within the Smith-Magenis syndrome region on chromosome 17. A pseudogene of this gene is located on the short arm of chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

Chromosome

 17

Cytoband

 p11.2

Chromosome location (bp)

 18327860 - 18363563

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000176974 (version 83.38)

Entrez gene

 6470

UniProt

 P34896 (UniProt - Evidence at protein level)

neXtProt

 NX_P34896

Antibodypedia

 SHMT1 antibodies

PROTEIN BROWSER
SHMT1-001
SHMT1-003
SHMT1-007
SHMT1-009
SHMT1-201
SHMT1-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SHMT1-001
ENSP00000318868
ENST00000316694
P34896 [Direct mapping]
Serine hydroxymethyltransferase, cytosolic
Show all
Enzymes
   ENZYME proteins
   Transferases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004372 [glycine hydroxymethyltransferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0006231 [dTMP biosynthetic process]
GO:0006544 [glycine metabolic process]
GO:0006545 [glycine biosynthetic process]
GO:0006563 [L-serine metabolic process]
GO:0006565 [L-serine catabolic process]
GO:0006766 [vitamin metabolic process]
GO:0006767 [water-soluble vitamin metabolic process]
GO:0008732 [L-allo-threonine aldolase activity]
GO:0009083 [branched-chain amino acid catabolic process]
GO:0009113 [purine nucleobase biosynthetic process]
GO:0016597 [amino acid binding]
GO:0016740 [transferase activity]
GO:0019264 [glycine biosynthetic process from serine]
GO:0030170 [pyridoxal phosphate binding]
GO:0034641 [cellular nitrogen compound metabolic process]
GO:0035999 [tetrahydrofolate interconversion]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0044281 [small molecule metabolic process]
GO:0045329 [carnitine biosynthetic process]
GO:0046655 [folic acid metabolic process]
GO:0051262 [protein tetramerization]
GO:0051289 [protein homotetramerization]
GO:0070062 [extracellular exosome]
GO:0070905 [serine binding]
GO:1904482 [cellular response to tetrahydrofolate]
Show all
 483 aa
53.1 kDa 		No 0
SHMT1-003
ENSP00000318805
ENST00000354098
P34896 [Direct mapping]
Serine hydroxymethyltransferase, cytosolic
Show all
Enzymes
   ENZYME proteins
   Transferases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004372 [glycine hydroxymethyltransferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006544 [glycine metabolic process]
GO:0006563 [L-serine metabolic process]
GO:0006565 [L-serine catabolic process]
GO:0006766 [vitamin metabolic process]
GO:0006767 [water-soluble vitamin metabolic process]
GO:0009083 [branched-chain amino acid catabolic process]
GO:0009113 [purine nucleobase biosynthetic process]
GO:0016740 [transferase activity]
GO:0030170 [pyridoxal phosphate binding]
GO:0034641 [cellular nitrogen compound metabolic process]
GO:0035999 [tetrahydrofolate interconversion]
GO:0042803 [protein homodimerization activity]
GO:0044281 [small molecule metabolic process]
GO:0045329 [carnitine biosynthetic process]
GO:0046655 [folic acid metabolic process]
GO:0051262 [protein tetramerization]
GO:0070062 [extracellular exosome]
GO:0070905 [serine binding]
GO:1904482 [cellular response to tetrahydrofolate]
Show all
 444 aa
49 kDa 		No 0
SHMT1-007
ENSP00000462041
ENST00000583780
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 1 aa
0.1 kDa 		No 0
SHMT1-009
ENSP00000462227
ENST00000582653
J3KRZ5 [Direct mapping]
Serine hydroxymethyltransferase, cytosolic
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0008152 [metabolic process]
GO:0016740 [transferase activity]
Show all
 167 aa
18.6 kDa 		No 0
SHMT1-201
ENSP00000345881
ENST00000352886
P34896 [Direct mapping]
Serine hydroxymethyltransferase, cytosolic
Show all
Enzymes
   ENZYME proteins
   Transferases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
FDA approved drug targets
   Small molecule drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004372 [glycine hydroxymethyltransferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006544 [glycine metabolic process]
GO:0006563 [L-serine metabolic process]
GO:0006565 [L-serine catabolic process]
GO:0006766 [vitamin metabolic process]
GO:0006767 [water-soluble vitamin metabolic process]
GO:0009083 [branched-chain amino acid catabolic process]
GO:0009113 [purine nucleobase biosynthetic process]
GO:0016740 [transferase activity]
GO:0030170 [pyridoxal phosphate binding]
GO:0034641 [cellular nitrogen compound metabolic process]
GO:0035999 [tetrahydrofolate interconversion]
GO:0042803 [protein homodimerization activity]
GO:0044281 [small molecule metabolic process]
GO:0045329 [carnitine biosynthetic process]
GO:0046655 [folic acid metabolic process]
GO:0051262 [protein tetramerization]
GO:0070062 [extracellular exosome]
GO:0070905 [serine binding]
GO:1904482 [cellular response to tetrahydrofolate]
Show all
 345 aa
37.7 kDa 		No 0
SHMT1-202
ENSP00000477782
ENST00000618902
A0A087WTD8 [Direct mapping]
Serine hydroxymethyltransferase, cytosolic
Show all
   SPOCTOPUS predicted membrane proteins
   Phobius predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008152 [metabolic process]
GO:0016740 [transferase activity]
Show all
 125 aa
13.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.