Cell atlas - C19orf18 - The Human Protein Atlas

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C19orf18

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS CUSTOM DATA

GENE/PROTEIN

Antibody validation

Dictionary
	Golgi apparatus

Human cell
	Golgi Apparatus

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GENERAL INFORMATION
Gene name	C19orf18
Gene description	Chromosome 19 open reading frame 18
Protein class	Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the Golgi apparatus.
RNA cell category	Cell line enhanced (HEK 293)
Protein evidence	Evidence at transcript level
Main location	Localized to the Golgi apparatus (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA014527
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (HEK 293) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the Golgi apparatus.

Main location

Golgi apparatus (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA014527	HEK 293	Golgi apparatus
	HPA014527	U-2 OS	Golgi apparatus

CUSTOM DATA


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Thumbnail	Antibody	Cell line	Assay	Description
	HPA014527	U-2 OS	Image	Co-localization with the cis-Golgi marker GM130/GOLGA2 (RRID:AB_398141) after the treatment of U-2 OS cells with brefeldin A (5 ug/ml) for 30 minutes to disrupt the ER to Golgi transport; GOLGA2 localizes together with proteins associated with the Golgi-matrix (PMID: 8557739). C19orf18 is a Golgi-matrix protein, as it co-localizes with the Golgi-matrix marker GOLGA2 after the treatment with BFA, but partly remains in the ER indicating a constant shuttling between ER and Golgi apparatus.
	HPA014527	U-2 OS	Image	Co-localization with the cis-Golgi marker GM130/GOLGA2 (RRID:AB_398141) for a refined protein localization within the Golgi apparatus in U-2 OS cells. C19orf18 localizes to the Golgi apparatus, and is only detected in the cis-Golgi compartment.

GENE INFORMATION
Gene name	C19orf18 (HGNC Symbol)
Synonyms	MGC41906
Description	Chromosome 19 open reading frame 18 (HGNC Symbol)
Entrez gene summary
Chromosome	19
Cytoband	q13.43
Chromosome location (bp)	57958437 - 57974534
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000177025 (version 83.38)
Entrez gene	147685
UniProt	Q8NEA5 (UniProt - Evidence at transcript level)
neXtProt	NX_Q8NEA5
Antibodypedia	C19orf18 antibodies

PROTEIN BROWSER

C19orf18-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
C19orf18-001 ENSP00000321519 ENST00000314391	Q8NEA5 [Direct mapping] Uncharacterized protein C19orf18 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0003674 [molecular_function] GO:0008150 [biological_process] GO:0016021 [integral component of membrane] GO:0070062 [extracellular exosome] Show all	215 aa 24.2 kDa	Yes	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.