Tissue expression of MAN1B1 - Summary - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

MAN1B1

TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	MAN1B1
Gene description	Mannosidase, alpha, class 1B, member 1
Protein class	Disease related genes Enzymes Plasma proteins Potential drug targets Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	5
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression with a granular pattern /BK

DATA RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA051516
	SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

N/A

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	MAN1B1 (HGNC Symbol)
Synonyms	MANA-ER, MRT15
Description	Mannosidase, alpha, class 1B, member 1 (HGNC Symbol)
Entrez gene summary	This gene encodes an enzyme belonging to the glycosyl hydrolase 47 family. This enzyme functions in N-glycan biosynthesis, and is a class I alpha-1,2-mannosidase that specifically converts Man9GlcNAc to Man8GlcNAc isomer B. It is required for N-glycan trimming to Man5-6GlcNAc2 in the endoplasmic-reticulum-associated degradation pathway. Mutations in this gene cause autosomal-recessive intellectual disability. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 11. [provided by RefSeq, Dec 2011]
Chromosome	9
Cytoband	q34.3
Chromosome location (bp)	137086927 - 137109187
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000177239 (version 83.38)
Entrez gene	11253
UniProt	Q9UKM7 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UKM7
Antibodypedia	MAN1B1 antibodies

PROTEIN BROWSER

MAN1B1-003	MAN1B1-004	MAN1B1-008	MAN1B1-015	MAN1B1-017

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MAN1B1-003 ENSP00000448658 ENST00000475449	H0YI64 [Direct mapping] Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004571 [mannosyl-oligosaccharide 1,2-alpha-mannosidase activity] GO:0005509 [calcium ion binding] GO:0008152 [metabolic process] GO:0016020 [membrane] Show all	270 aa 29.5 kDa	No	0
MAN1B1-004 ENSP00000360645 ENST00000371589	Q9UKM7 [Direct mapping] Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase Show all	Enzymes ENZYME proteins Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004571 [mannosyl-oligosaccharide 1,2-alpha-mannosidase activity] GO:0005509 [calcium ion binding] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0005794 [Golgi apparatus] GO:0006457 [protein folding] GO:0006487 [protein N-linked glycosylation] GO:0006491 [N-glycan processing] GO:0009311 [oligosaccharide metabolic process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0030433 [ER-associated ubiquitin-dependent protein catabolic process] GO:0036508 [protein alpha-1,2-demannosylation] GO:0036509 [trimming of terminal mannose on B branch] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0044322 [endoplasmic reticulum quality control compartment] GO:0097466 [glycoprotein ERAD pathway] GO:1903561 [extracellular vesicle] GO:1904380 [endoplasmic reticulum mannose trimming] GO:1904382 [mannose trimming involved in glycoprotein ERAD pathway] Show all	699 aa 79.6 kDa	No	1
MAN1B1-008 ENSP00000441398 ENST00000535144	H0YG20 [Direct mapping] alpha-1,2-Mannosidase Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004571 [mannosyl-oligosaccharide 1,2-alpha-mannosidase activity] GO:0005509 [calcium ion binding] GO:0008152 [metabolic process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	695 aa 79 kDa	No	1
MAN1B1-015 ENSP00000444189 ENST00000542372	H0YGQ1 [Direct mapping] Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004571 [mannosyl-oligosaccharide 1,2-alpha-mannosidase activity] GO:0005509 [calcium ion binding] GO:0008152 [metabolic process] GO:0016021 [integral component of membrane] Show all	182 aa 20.8 kDa	No	1
MAN1B1-017 ENSP00000450147 ENST00000550113	H0YIU0 [Direct mapping] Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004571 [mannosyl-oligosaccharide 1,2-alpha-mannosidase activity] GO:0005509 [calcium ion binding] GO:0008152 [metabolic process] GO:0016020 [membrane] Show all	124 aa 14.6 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.