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TOP3A

CANCER ATLAS

Gene description

 Topoisomerase (DNA) III alpha

Protein class

 Cancer-related genes, Enzymes, Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
CAB002449

GENE INFORMATION

Gene name

 TOP3A (HGNC Symbol)

Synonyms

 TOP3, ZGRF7

Description

 Topoisomerase (DNA) III alpha (HGNC Symbol)

Entrez gene summary

 This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus reducing the number of supercoils and altering the topology of DNA. This enzyme forms a complex with BLM which functions in the regulation of recombination in somatic cells. [provided by RefSeq, Jul 2008]

Chromosome

 17

Cytoband

 p11.2

Chromosome location (bp)

 18271428 - 18315007

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000177302 (version 83.38)

Entrez gene

 7156

UniProt

 Q13472 (UniProt - Evidence at protein level)

neXtProt

 NX_Q13472

Antibodypedia

 TOP3A antibodies

PROTEIN BROWSER
TOP3A-001
TOP3A-008
TOP3A-020
TOP3A-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TOP3A-001
ENSP00000321636
ENST00000321105
Q13472 [Direct mapping]
DNA topoisomerase 3-alpha
Show all
Enzymes
   ENZYME proteins
   Isomerase
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000724 [double-strand break repair via homologous recombination]
GO:0003677 [DNA binding]
GO:0003916 [DNA topoisomerase activity]
GO:0003917 [DNA topoisomerase type I activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005694 [chromosome]
GO:0006265 [DNA topological change]
GO:0006281 [DNA repair]
GO:0006302 [double-strand break repair]
GO:0007126 [meiotic nuclear division]
GO:0008270 [zinc ion binding]
GO:0016605 [PML body]
GO:0045003 [double-strand break repair via synthesis-dependent strand annealing]
Show all
 1001 aa
112.4 kDa 		No 0
TOP3A-008
ENSP00000465864
ENST00000489131
K7EL07 [Direct mapping]
DNA topoisomerase 3-alpha
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0008270 [zinc ion binding]
Show all
 25 aa
2.8 kDa 		No 0
TOP3A-020
ENSP00000462790
ENST00000580095
Q13472 [Direct mapping]
DNA topoisomerase 3-alpha
Show all
Enzymes
   ENZYME proteins
   Isomerase
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000724 [double-strand break repair via homologous recombination]
GO:0003677 [DNA binding]
GO:0003916 [DNA topoisomerase activity]
GO:0003917 [DNA topoisomerase type I activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005694 [chromosome]
GO:0006265 [DNA topological change]
GO:0006281 [DNA repair]
GO:0006302 [double-strand break repair]
GO:0007126 [meiotic nuclear division]
GO:0008270 [zinc ion binding]
GO:0016605 [PML body]
GO:0045003 [double-strand break repair via synthesis-dependent strand annealing]
Show all
 976 aa
109.3 kDa 		No 0
TOP3A-201
ENSP00000442336
ENST00000542570
Q13472 [Direct mapping]
DNA topoisomerase 3-alpha
Show all
Enzymes
   ENZYME proteins
   Isomerase
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000724 [double-strand break repair via homologous recombination]
GO:0003677 [DNA binding]
GO:0003916 [DNA topoisomerase activity]
GO:0003917 [DNA topoisomerase type I activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005694 [chromosome]
GO:0006265 [DNA topological change]
GO:0006281 [DNA repair]
GO:0006302 [double-strand break repair]
GO:0007126 [meiotic nuclear division]
GO:0008270 [zinc ion binding]
GO:0016605 [PML body]
GO:0045003 [double-strand break repair via synthesis-dependent strand annealing]
Show all
 1001 aa
112.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.