Cell atlas - ZBTB38 - The Human Protein Atlas

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ZBTB38

TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoplasm

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	ZBTB38
Gene description	Zinc finger and BTB domain containing 38
Protein class	Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	13
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleoplasm.
RNA cell category	Cell line enhanced (RPMI-8226)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (validated)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Validated based on 2 antibodies. HPA014865 , HPA059378
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (RPMI-8226) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleoplasm.

Main location

Nucleoplasm (validated)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA014865	A-431	Nucleoplasm	Intensity
	HPA014865	U-2 OS	Nucleoplasm	Intensity
	HPA014865	U-251 MG	Nucleoplasm	Intensity
	HPA059378	A-431	Nucleoplasm	Intensity
	HPA059378	U-2 OS	No staining
	HPA059378	U-251 MG	Nucleoplasm	Intensity

GENE INFORMATION
Gene name	ZBTB38 (HGNC Symbol)
Synonyms	CIBZ, FLJ35036, PPP1R171, ZNF921
Description	Zinc finger and BTB domain containing 38 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a zinc finger transcriptional activator that binds methylated DNA. The encoded protein can form homodimers or heterodimers through the zinc finger domains. In mouse, inhibition of this protein has been associated with apoptosis in some cell types. [provided by RefSeq, Jun 2010]
Chromosome	3
Cytoband	q23
Chromosome location (bp)	141324213 - 141449792
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000177311 (version 83.38)
Entrez gene	253461
UniProt	Q8NAP3 (UniProt - Evidence at protein level)
neXtProt	NX_Q8NAP3
Antibodypedia	ZBTB38 antibodies

PROTEIN BROWSER

ZBTB38-001	ZBTB38-002	ZBTB38-005	ZBTB38-006	ZBTB38-007	ZBTB38-010	ZBTB38-012	ZBTB38-013	ZBTB38-016	ZBTB38-017	ZBTB38-018	ZBTB38-019	ZBTB38-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ZBTB38-001 ENSP00000426387 ENST00000514251	Q8NAP3 [Direct mapping] Zinc finger and BTB domain-containing protein 38 Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005694 [chromosome] GO:0006275 [regulation of DNA replication] GO:0006351 [transcription, DNA-templated] GO:0006974 [cellular response to DNA damage stimulus] GO:0008327 [methyl-CpG binding] GO:0042803 [protein homodimerization activity] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046872 [metal ion binding] GO:0072562 [blood microparticle] Show all	1195 aa 134.3 kDa	No	0
ZBTB38-002 ENSP00000426931 ENST00000509842	D6RE69 [Direct mapping] Zinc finger and BTB domain-containing protein 38 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	150 aa 16.9 kDa	No	0
ZBTB38-005 ENSP00000424254 ENST00000509883	D6RBC4 [Direct mapping] Zinc finger and BTB domain-containing protein 38 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0005515 [protein binding] GO:0046872 [metal ion binding] Show all	771 aa 85.8 kDa	No	0
ZBTB38-006 ENSP00000422757 ENST00000513570	D6RAC4 [Direct mapping] Zinc finger and BTB domain-containing protein 38 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	70 aa 8 kDa	No	0
ZBTB38-007 ENSP00000406955 ENST00000441582	Q8NAP3 [Direct mapping] Zinc finger and BTB domain-containing protein 38 Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Protein evidence (Ezkurdia et al 2014) Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005694 [chromosome] GO:0006275 [regulation of DNA replication] GO:0006351 [transcription, DNA-templated] GO:0006974 [cellular response to DNA damage stimulus] GO:0008327 [methyl-CpG binding] GO:0042803 [protein homodimerization activity] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046872 [metal ion binding] GO:0072562 [blood microparticle] Show all	1195 aa 134.3 kDa	No	0
ZBTB38-010 ENSP00000421037 ENST00000507722	D6RHD1 [Direct mapping] Zinc finger and BTB domain-containing protein 38 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	118 aa 13.3 kDa	No	0
ZBTB38-012 ENSP00000422051 ENST00000503809	D6R9J6 [Direct mapping] Zinc finger and BTB domain-containing protein 38 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		34 aa 3.9 kDa	No	0
ZBTB38-013 ENSP00000426288 ENST00000513258	D6RGK1 [Direct mapping] Zinc finger and BTB domain-containing protein 38 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	108 aa 12.3 kDa	No	0
ZBTB38-016 ENSP00000425705 ENST00000510338	D6RJE1 [Direct mapping] Zinc finger and BTB domain-containing protein 38 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	146 aa 16.4 kDa	No	0
ZBTB38-017 ENSP00000422347 ENST00000504673	D6RC86 [Direct mapping] Zinc finger and BTB domain-containing protein 38 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	94 aa 10.8 kDa	No	0
ZBTB38-018 ENSP00000422081 ENST00000510726	D6R9I1 [Direct mapping] Zinc finger and BTB domain-containing protein 38 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	210 aa 23.7 kDa	No	0
ZBTB38-019 ENSP00000422894 ENST00000509813	D6R9U6 [Direct mapping] Zinc finger and BTB domain-containing protein 38 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	111 aa 12.5 kDa	No	0
ZBTB38-201 ENSP00000372635 ENST00000321464	Q8NAP3 [Direct mapping] Zinc finger and BTB domain-containing protein 38 Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Protein evidence (Ezkurdia et al 2014) Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005694 [chromosome] GO:0006275 [regulation of DNA replication] GO:0006351 [transcription, DNA-templated] GO:0006974 [cellular response to DNA damage stimulus] GO:0008327 [methyl-CpG binding] GO:0042803 [protein homodimerization activity] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046872 [metal ion binding] GO:0072562 [blood microparticle] Show all	1195 aa 134.3 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.