Cell atlas - ARIH2 - The Human Protein Atlas

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ARIH2

TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoplasm

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	ARIH2
Gene description	Ariadne RBR E3 ubiquitin protein ligase 2
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleoplasm.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (validated)

DATA RELIABILITY
Reliability score	Validated based on 3 antibodies. HPA067381 , HPA069715 , HPA070963
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleoplasm.

Main location

Nucleoplasm (validated)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA067381	HEK 293	Nucleoplasm
	HPA067381	U-2 OS	Nucleoplasm
	HPA067381	U-251 MG	Nucleoplasm
	HPA069715	SiHa	Nucleoplasm
	HPA069715	U-2 OS	Nucleoplasm
	HPA069715	U-251 MG	Nucleoplasm
	HPA070963	PC-3	Nucleoplasm
	HPA070963	RT4	Nucleoplasm
	HPA070963	U-2 OS	Nucleoplasm

GENE INFORMATION
Gene name	ARIH2 (HGNC Symbol)
Synonyms	TRIAD1
Description	Ariadne RBR E3 ubiquitin protein ligase 2 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is an E3 ubiquitin-protein ligase that polyubiquitinates some proteins, tagging them for degradation. The encoded protein upregulates p53 in some cancer cells and may inhibit myelopoiesis. Several transcript variants encoding different isoforms have been found for this gene, although the full-length nature of some of them have not been determined yet. [provided by RefSeq, Nov 2015]
Chromosome	3
Cytoband	p21.31
Chromosome location (bp)	48918821 - 48986382
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000177479 (version 83.38)
Entrez gene	10425
UniProt	O95376 (UniProt - Evidence at protein level)
neXtProt	NX_O95376
Antibodypedia	ARIH2 antibodies

PROTEIN BROWSER

ARIH2-001	ARIH2-002	ARIH2-010	ARIH2-017	ARIH2-018	ARIH2-019	ARIH2-024

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ARIH2-001 ENSP00000348769 ENST00000356401	O95376 [Direct mapping] E3 ubiquitin-protein ligase ARIH2 Q6IBL8 [Target identity:100%; Query identity:100%] ARIH2 protein; Ariadne homolog 2 (Drosophila), isoform CRA_a; cDNA, FLJ93973, Homo sapiens ariadne homolog 2 (Drosophila) (ARIH2), mRNA Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000151 [ubiquitin ligase complex] GO:0000209 [protein polyubiquitination] GO:0003676 [nucleic acid binding] GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006511 [ubiquitin-dependent protein catabolic process] GO:0007275 [multicellular organismal development] GO:0008270 [zinc ion binding] GO:0016874 [ligase activity] GO:0031624 [ubiquitin conjugating enzyme binding] GO:0032436 [positive regulation of proteasomal ubiquitin-dependent protein catabolic process] GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process] GO:0048588 [developmental cell growth] GO:0061630 [ubiquitin protein ligase activity] GO:0070534 [protein K63-linked ubiquitination] GO:0070936 [protein K48-linked ubiquitination] GO:0071425 [hematopoietic stem cell proliferation] GO:1903955 [positive regulation of protein targeting to mitochondrion] Show all	493 aa 57.8 kDa	No	0
ARIH2-002 ENSP00000403222 ENST00000449376	O95376 [Direct mapping] E3 ubiquitin-protein ligase ARIH2 Q6IBL8 [Target identity:100%; Query identity:100%] ARIH2 protein; Ariadne homolog 2 (Drosophila), isoform CRA_a; cDNA, FLJ93973, Homo sapiens ariadne homolog 2 (Drosophila) (ARIH2), mRNA Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000151 [ubiquitin ligase complex] GO:0000209 [protein polyubiquitination] GO:0003676 [nucleic acid binding] GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0007275 [multicellular organismal development] GO:0008270 [zinc ion binding] GO:0016874 [ligase activity] GO:0031624 [ubiquitin conjugating enzyme binding] GO:0032436 [positive regulation of proteasomal ubiquitin-dependent protein catabolic process] GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process] GO:0048588 [developmental cell growth] GO:0061630 [ubiquitin protein ligase activity] GO:0070534 [protein K63-linked ubiquitination] GO:0070936 [protein K48-linked ubiquitination] GO:0071425 [hematopoietic stem cell proliferation] GO:1903955 [positive regulation of protein targeting to mitochondrion] Show all	493 aa 57.8 kDa	No	0
ARIH2-010 ENSP00000395560 ENST00000452882	C9JBC5 [Direct mapping] E3 ubiquitin-protein ligase ARIH2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004842 [ubiquitin-protein transferase activity] GO:0016567 [protein ubiquitination] Show all	107 aa 12.1 kDa	No	0
ARIH2-017 ENSP00000397225 ENST00000420814	C9JBC5 [Direct mapping] E3 ubiquitin-protein ligase ARIH2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004842 [ubiquitin-protein transferase activity] GO:0016567 [protein ubiquitination] Show all	107 aa 12.1 kDa	No	0
ARIH2-018 ENSP00000404838 ENST00000449729	C9JCL4 [Direct mapping] E3 ubiquitin-protein ligase ARIH2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		85 aa 9.5 kDa	No	0
ARIH2-019 ENSP00000406063 ENST00000433170	C9JAU2 [Direct mapping] E3 ubiquitin-protein ligase ARIH2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		56 aa 6.2 kDa	No	0
ARIH2-024 ENSP00000399788 ENST00000430423	C9JZ71 [Direct mapping] E3 ubiquitin-protein ligase ARIH2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004842 [ubiquitin-protein transferase activity] GO:0016567 [protein ubiquitination] Show all	138 aa 15.6 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.