Cell atlas - IRX3 - The Human Protein Atlas

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IRX3

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Vesicles

Human cell
	Vesicles

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GENERAL INFORMATION
Gene name	IRX3
Gene description	Iroquois homeobox 3
Protein class	Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to vesicles.
RNA cell category	Cell line enhanced (RPTEC TERT1, THP-1, NB-4, T-47d)
Protein evidence	Evidence at protein level
Main location	Localized to the Vesicles (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA062522
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (RPTEC TERT1, THP-1, NB-4, T-47d) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to vesicles.

Main location

Vesicles (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA062522	HEK 293	Vesicles
	HPA062522	HeLa	No staining
	HPA062522	U-2 OS	Vesicles

GENE INFORMATION
Gene name	IRX3 (HGNC Symbol)
Synonyms	IRX-1
Description	Iroquois homeobox 3 (HGNC Symbol)
Entrez gene summary	IRX3 is a member of the Iroquois homeobox gene family (see IRX1; MIM 606197) and plays a role in an early step of neural development (Bellefroid et al., 1998 [PubMed 9427753]). Members of this family appear to play multiple roles during pattern formation of vertebrate embryos (Lewis et al., 1999 [PubMed 10370142]).[supplied by OMIM, Aug 2009]
Chromosome	16
Cytoband	q12.2
Chromosome location (bp)	54283304 - 54286763
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000177508 (version 83.38)
Entrez gene	79191
UniProt	P78415 (UniProt - Evidence at transcript level)
neXtProt	NX_P78415
Antibodypedia	IRX3 antibodies

PROTEIN BROWSER

IRX3-001	IRX3-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
IRX3-001 ENSP00000331608 ENST00000329734	P78415 [Direct mapping] Iroquois-class homeodomain protein IRX-3 Show all	Predicted intracellular proteins Transcription factors Helix-turn-helix domains Show all	GO:0001656 [metanephros development] GO:0003677 [DNA binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0007498 [mesoderm development] GO:0030424 [axon] GO:0043565 [sequence-specific DNA binding] GO:0045665 [negative regulation of neuron differentiation] GO:0045666 [positive regulation of neuron differentiation] GO:0072047 [proximal/distal pattern formation involved in nephron development] GO:0072086 [specification of loop of Henle identity] Show all	501 aa 52.1 kDa	No	0
IRX3-003 ENSP00000463991 ENST00000558054	J3QR11 [Direct mapping] Iroquois-class homeodomain protein IRX-3 Show all	Predicted intracellular proteins Show all		84 aa 9.4 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.