Tissue expression of SLC25A22 - Summary - The Human Protein Atlas

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SLC25A22

TISSUE

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CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	SLC25A22
Gene description	Solute carrier family 25 (mitochondrial carrier: glutamate), member 22
Protein class	Disease related genes Plasma proteins Potential drug targets Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	19
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enriched (cerebral cortex)
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in most tissues, including CNS.

DATA RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA014662
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (cerebral cortex)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	SLC25A22 (HGNC Symbol)
Synonyms	EIEE3, FLJ13044, GC1, NET44
Description	Solute carrier family 25 (mitochondrial carrier: glutamate), member 22 (HGNC Symbol)
Entrez gene summary	This gene encodes a mitochondrial glutamate carrier. Mutations in this gene are associated with early infantile epileptic encephalopathy. Multiple alternatively spliced variants, encoding the same protein, have been identified.[provided by RefSeq, Jul 2010]
Chromosome	11
Cytoband	p15.5
Chromosome location (bp)	790475 - 798333
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000177542 (version 83.38)
Entrez gene	79751
UniProt	Q9H936 (UniProt - Evidence at protein level)
neXtProt	NX_Q9H936
Antibodypedia	SLC25A22 antibodies

PROTEIN BROWSER

SLC25A22-001	SLC25A22-002	SLC25A22-003	SLC25A22-004	SLC25A22-006	SLC25A22-007	SLC25A22-008	SLC25A22-009	SLC25A22-012	SLC25A22-013	SLC25A22-014	SLC25A22-015	SLC25A22-016	SLC25A22-018	SLC25A22-023	SLC25A22-024	SLC25A22-027	SLC25A22-029	SLC25A22-030

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC25A22-001 ENSP00000322020 ENST00000320230	Q9H936 [Direct mapping] Mitochondrial glutamate carrier 1 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005313 [L-glutamate transmembrane transporter activity] GO:0005654 [nucleoplasm] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0015293 [symporter activity] GO:0015813 [L-glutamate transport] GO:0016021 [integral component of membrane] GO:0089711 [L-glutamate transmembrane transport] Show all	323 aa 34.5 kDa	No	4
SLC25A22-002 ENSP00000392749 ENST00000456706	K4DIA2 [Direct mapping] Mitochondrial glutamate carrier 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] Show all	115 aa 12.4 kDa	No	1
SLC25A22-003 ENSP00000431829 ENST00000481290	E9PJH7 [Direct mapping] Mitochondrial glutamate carrier 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005654 [nucleoplasm] GO:0005739 [mitochondrion] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] Show all	313 aa 33.3 kDa	No	3
SLC25A22-004 ENSP00000437236 ENST00000531214	Q9H936 [Direct mapping] Mitochondrial glutamate carrier 1 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005313 [L-glutamate transmembrane transporter activity] GO:0005654 [nucleoplasm] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0015293 [symporter activity] GO:0015813 [L-glutamate transport] GO:0016021 [integral component of membrane] GO:0089711 [L-glutamate transmembrane transport] Show all	323 aa 34.5 kDa	No	4
SLC25A22-006 ENSP00000431466 ENST00000532484	K4DIA8 [Direct mapping] Mitochondrial glutamate carrier 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] Show all	190 aa 20.3 kDa	No	1
SLC25A22-007 ENSP00000435402 ENST00000531534	K4DIB6 [Direct mapping] Mitochondrial glutamate carrier 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] Show all	156 aa 16.7 kDa	No	1
SLC25A22-008 ENSP00000434850 ENST00000530360	K4DIB4 [Direct mapping] Mitochondrial glutamate carrier 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0006810 [transport] GO:0016021 [integral component of membrane] Show all	65 aa 7.1 kDa	No	1
SLC25A22-009 ENSP00000486058 ENST00000628067	Q9H936 [Direct mapping] Mitochondrial glutamate carrier 1 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005313 [L-glutamate transmembrane transporter activity] GO:0005654 [nucleoplasm] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0015293 [symporter activity] GO:0015813 [L-glutamate transport] GO:0016021 [integral component of membrane] GO:0089711 [L-glutamate transmembrane transport] Show all	323 aa 34.5 kDa	No	4
SLC25A22-012 ENSP00000437045 ENST00000528606	K4DIB8 [Direct mapping] Mitochondrial glutamate carrier 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] Show all	177 aa 18.9 kDa	No	1
SLC25A22-013 ENSP00000487237 ENST00000625752	A0A0D9SG84 [Direct mapping] Mitochondrial glutamate carrier 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] Show all	118 aa 12.7 kDa	No	1
SLC25A22-014 ENSP00000434479 ENST00000527723	E9PQ36 [Direct mapping] Mitochondrial glutamate carrier 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] Show all	134 aa 14.5 kDa	No	1
SLC25A22-015 ENSP00000436745 ENST00000526152	E9PI74 [Direct mapping] Mitochondrial glutamate carrier 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] Show all	127 aa 13.8 kDa	No	1
SLC25A22-016 ENSP00000433028 ENST00000529066	A0A0A6YYN8 [Direct mapping] Mitochondrial glutamate carrier 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0006810 [transport] GO:0016021 [integral component of membrane] Show all	78 aa 8.4 kDa	No	1
SLC25A22-018 ENSP00000486512 ENST00000627843	A0A0D9SFE1 [Direct mapping] Mitochondrial glutamate carrier 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] Show all	247 aa 26.2 kDa	No	3
SLC25A22-023 ENSP00000435862 ENST00000531437	E9PS95 [Direct mapping] Mitochondrial glutamate carrier 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005654 [nucleoplasm] GO:0005739 [mitochondrion] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] Show all	196 aa 20.8 kDa	No	1
SLC25A22-024 ENSP00000485719 ENST00000625419	A0A0D9SEI9 [Direct mapping] Mitochondrial glutamate carrier 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] Show all	197 aa 21 kDa	No	1
SLC25A22-027 ENSP00000486434 ENST00000629634	A0A0D9SFA8 [Direct mapping] Mitochondrial glutamate carrier 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] Show all	97 aa 10.6 kDa	No	1
SLC25A22-029 ENSP00000432817 ENST00000528936	K4DIB0 [Direct mapping] Mitochondrial glutamate carrier 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] Show all	103 aa 11.3 kDa	No	1
SLC25A22-030 ENSP00000434287 ENST00000533385	K4DIB3 [Direct mapping] Mitochondrial glutamate carrier 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] Show all	161 aa 17.2 kDa	No	1

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The Human Protein Atlas

The Human Protein Atlas project is funded
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