Cell atlas - ATOX1 - The Human Protein Atlas

GENERAL INFORMATION
Gene name	ATOX1
Gene description	Antioxidant 1 copper chaperone
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleoplasm. In addition localized to the plasma membrane.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (approved)
Additional location	In addition localized to the Plasma membrane (approved)
Mouse	Localized to the Cytosol in mouse cells.

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA055036
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ASSAYS

RNA expression

Human cells

Mouse cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleoplasm. In addition localized to the plasma membrane.

Main location

Nucleoplasm (approved)

Additional location

Plasma membrane (approved)


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Antibody	Cell line	Location
HPA055036	PC-3	Nucleoplasm
HPA055036	U-2 OS	Nucleoplasm
HPA055036	U-2 OS	Plasma membrane

MOUSE CELLS

Main location

Cytosol

Mouse gene

ENSMUSG00000018585 (version 83)


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Thumbnail	Antibody	Cell line	Location
	HPA055036	NIH 3T3	Cytosol

GENE INFORMATION
Gene name	ATOX1 (HGNC Symbol)
Synonyms	HAH1
Description	Antioxidant 1 copper chaperone (HGNC Symbol)
Entrez gene summary	This gene encodes a copper chaperone that plays a role in copper homeostasis by binding and transporting cytosolic copper to ATPase proteins in the trans-Golgi network for later incorporation to the ceruloplasmin. This protein also functions as an antioxidant against superoxide and hydrogen peroxide, and therefore, may play a significant role in cancer carcinogenesis. Because of its cytogenetic location, this gene represents a candidate gene for 5q-syndrome. [provided by RefSeq, Jul 2008]
Chromosome	5
Cytoband	q33.1
Chromosome location (bp)	151742316 - 151772532
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000177556 (version 83.38)
Entrez gene	475
UniProt	O00244 (UniProt - Evidence at protein level)
neXtProt	NX_O00244
Antibodypedia	ATOX1 antibodies

PROTEIN BROWSER

ATOX1-001	ATOX1-002	ATOX1-003	ATOX1-004	ATOX1-006	ATOX1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ATOX1-001 ENSP00000430598 ENST00000524142	O00244 [Direct mapping] Copper transport protein ATOX1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000302 [response to reactive oxygen species] GO:0005375 [copper ion transmembrane transporter activity] GO:0005507 [copper ion binding] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0006825 [copper ion transport] GO:0006878 [cellular copper ion homeostasis] GO:0006979 [response to oxidative stress] GO:0015680 [intracellular copper ion transport] GO:0016530 [metallochaperone activity] GO:0016531 [copper chaperone activity] GO:0030001 [metal ion transport] GO:0032767 [copper-dependent protein binding] GO:0035434 [copper ion transmembrane transport] GO:0046872 [metal ion binding] Show all	68 aa 7.4 kDa	No	0
ATOX1-002 ENSP00000429366 ENST00000521264	E5RIM7 [Direct mapping] Copper transport protein ATOX1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0030001 [metal ion transport] GO:0046872 [metal ion binding] Show all	73 aa 7.9 kDa	No	0
ATOX1-003 ENSP00000429814 ENST00000522710	O00244 [Direct mapping] Copper transport protein ATOX1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000302 [response to reactive oxygen species] GO:0005507 [copper ion binding] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0006825 [copper ion transport] GO:0006979 [response to oxidative stress] GO:0015680 [intracellular copper ion transport] GO:0016530 [metallochaperone activity] GO:0016531 [copper chaperone activity] GO:0030001 [metal ion transport] GO:0032767 [copper-dependent protein binding] GO:0046872 [metal ion binding] Show all	68 aa 7.4 kDa	No	0
ATOX1-004 ENSP00000429982 ENST00000520382	E5RGN3 [Direct mapping] Copper transport protein ATOX1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0030001 [metal ion transport] GO:0046872 [metal ion binding] Show all	59 aa 6.3 kDa	No	0
ATOX1-006 ENSP00000430028 ENST00000522314	E5RGN3 [Direct mapping] Copper transport protein ATOX1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0030001 [metal ion transport] GO:0046872 [metal ion binding] Show all	59 aa 6.3 kDa	No	0
ATOX1-201 ENSP00000316854 ENST00000313115	O00244 [Direct mapping] Copper transport protein ATOX1 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000302 [response to reactive oxygen species] GO:0005507 [copper ion binding] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0006825 [copper ion transport] GO:0006979 [response to oxidative stress] GO:0015680 [intracellular copper ion transport] GO:0016530 [metallochaperone activity] GO:0016531 [copper chaperone activity] GO:0030001 [metal ion transport] GO:0032767 [copper-dependent protein binding] GO:0046872 [metal ion binding] Show all	68 aa 7.4 kDa	No	0