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PIDD1

CANCER ATLAS

Gene description

 P53-induced death domain protein 1

Protein class

 Enzymes, Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
CAB012647

GENE INFORMATION

Gene name

 PIDD1 (HGNC Symbol)

Synonyms

 DKFZp434D229, LRDD, MGC16925, PIDD

Description

 P53-induced death domain protein 1 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene contains a leucine-rich repeat and a death domain. This protein has been shown to interact with other death domain proteins, such as Fas (TNFRSF6)-associated via death domain (FADD) and MAP-kinase activating death domain-containing protein (MADD), and thus may function as an adaptor protein in cell death-related signaling processes. The expression of the mouse counterpart of this gene has been found to be positively regulated by the tumor suppressor p53 and to induce cell apoptosis in response to DNA damage, which suggests a role for this gene as an effector of p53-dependent apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2010]

Chromosome

 11

Cytoband

 p15.5

Chromosome location (bp)

 799179 - 809753

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000177595 (version 83.38)

Entrez gene

 55367

UniProt

 Q9HB75 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9HB75

Antibodypedia

 PIDD1 antibodies

PROTEIN BROWSER
PIDD1-001
PIDD1-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PIDD1-001
ENSP00000337797
ENST00000347755
Q9HB75 [Direct mapping]
p53-induced death domain-containing protein 1
Show all
Enzymes
   Peptidases
   Serine-type peptidases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Show all
GO:0005123 [death receptor binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0006915 [apoptotic process]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest]
GO:0007165 [signal transduction]
GO:0043065 [positive regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:1902043 [positive regulation of extrinsic apoptotic signaling pathway via death domain receptors]
GO:2001235 [positive regulation of apoptotic signaling pathway]
GO:2001238 [positive regulation of extrinsic apoptotic signaling pathway]
Show all
 910 aa
99.7 kDa 		No 0
PIDD1-002
ENSP00000416801
ENST00000411829
Q9HB75 [Direct mapping]
p53-induced death domain-containing protein 1
Show all
Enzymes
   Peptidases
   Serine-type peptidases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Show all
GO:0005123 [death receptor binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0006915 [apoptotic process]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest]
GO:0007165 [signal transduction]
GO:0043065 [positive regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
Show all
 893 aa
97.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.