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RPLP2

GENERAL INFORMATION

Gene name

 RPLP2

Gene description

 Ribosomal protein, large, P2

Protein class

 Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins
Ribosomal proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 General cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

 Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA053635
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Urinary bladder

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 RPLP2 (HGNC Symbol)

Synonyms

 D11S2243E, LP2, MGC71408, P2, RPP2

Description

 Ribosomal protein, large, P2 (HGNC Symbol)

Entrez gene summary

 Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal phosphoprotein that is a component of the 60S subunit. The protein, which is a functional equivalent of the E. coli L7/L12 ribosomal protein, belongs to the L12P family of ribosomal proteins. It plays an important role in the elongation step of protein synthesis. Unlike most ribosomal proteins, which are basic, the encoded protein is acidic. Its C-terminal end is nearly identical to the C-terminal ends of the ribosomal phosphoproteins P0 and P1. The P2 protein can interact with P0 and P1 to form a pentameric complex consisting of P1 and P2 dimers, and a P0 monomer. The protein is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

Chromosome

 11

Cytoband

 p15.5

Chromosome location (bp)

 809647 - 812880

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000177600 (version 83.38)

Entrez gene

 6181

UniProt

 P05387 (UniProt - Evidence at protein level)

neXtProt

 NX_P05387

Antibodypedia

 RPLP2 antibodies

PROTEIN BROWSER
RPLP2-001
RPLP2-002
RPLP2-009

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RPLP2-001
ENSP00000322419
ENST00000321153
P05387 [Direct mapping]
60S acidic ribosomal protein P2
A0A024RCA7 [Target identity:100%; Query identity:100%]
Ribosomal protein, large, P2, isoform CRA_a
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Ribosomal proteins
   SPOCTOPUS predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000184 [nuclear-transcribed mRNA catabolic process, nonsense-mediated decay]
GO:0003723 [RNA binding]
GO:0003735 [structural constituent of ribosome]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005925 [focal adhesion]
GO:0006412 [translation]
GO:0006413 [translational initiation]
GO:0006414 [translational elongation]
GO:0006415 [translational termination]
GO:0006614 [SRP-dependent cotranslational protein targeting to membrane]
GO:0010467 [gene expression]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0019058 [viral life cycle]
GO:0019083 [viral transcription]
GO:0022625 [cytosolic large ribosomal subunit]
GO:0044267 [cellular protein metabolic process]
GO:0070062 [extracellular exosome]
Show all
 115 aa
11.7 kDa 		Yes 0
RPLP2-002
ENSP00000431240
ENST00000530797
P05387 [Direct mapping]
60S acidic ribosomal protein P2
A0A024RCA7 [Target identity:100%; Query identity:100%]
Ribosomal protein, large, P2, isoform CRA_a
Show all
Ribosomal proteins
   SPOCTOPUS predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000184 [nuclear-transcribed mRNA catabolic process, nonsense-mediated decay]
GO:0003723 [RNA binding]
GO:0003735 [structural constituent of ribosome]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005925 [focal adhesion]
GO:0006412 [translation]
GO:0006413 [translational initiation]
GO:0006414 [translational elongation]
GO:0006415 [translational termination]
GO:0006614 [SRP-dependent cotranslational protein targeting to membrane]
GO:0010467 [gene expression]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0019058 [viral life cycle]
GO:0019083 [viral transcription]
GO:0022625 [cytosolic large ribosomal subunit]
GO:0044267 [cellular protein metabolic process]
GO:0070062 [extracellular exosome]
Show all
 115 aa
11.7 kDa 		Yes 0
RPLP2-009
ENSP00000433443
ENST00000530398
H0YDD8 [Direct mapping]
60S acidic ribosomal protein P2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003735 [structural constituent of ribosome]
GO:0005840 [ribosome]
GO:0006414 [translational elongation]
Show all
 92 aa
9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.