Cell atlas - FAM20C - The Human Protein Atlas

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FAM20C

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Golgi apparatus
	Nucleoplasm

Human cell
	Cytosol
	Golgi Apparatus
	Nucleoplasm

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GENERAL INFORMATION
Gene name	FAM20C
Gene description	Family with sequence similarity 20, member C
Protein class	Disease related genes Enzymes Plasma proteins Potential drug targets Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleoplasm. In addition localized to the cytosol & the Golgi apparatus.
RNA cell category	Cell line enhanced (U-87 MG, WM-115)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (approved)
Additional location	In addition localized to the Golgi apparatus (approved), Cytosol (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA019823
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (U-87 MG, WM-115) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleoplasm. In addition localized to the cytosol & the Golgi apparatus.

Main location

Nucleoplasm (approved)

Additional location

Golgi apparatus (approved), Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA019823	A-431	Nucleoplasm
	HPA019823	A-431	Golgi apparatus
	HPA019823	U-2 OS	Nucleoplasm
	HPA019823	U-2 OS	Cytosol

GENE INFORMATION
Gene name	FAM20C (HGNC Symbol)
Synonyms	DKFZp547D065, DMP4, IMAGE:4942737
Description	Family with sequence similarity 20, member C (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the family of secreted protein kinases. The encoded protein binds calcium and phosphorylates proteins involved in bone mineralization. Mutations in this gene are associated with the autosomal recessive disorder Raine syndrome. [provided by RefSeq, Apr 2014]
Chromosome	7
Cytoband	p22.3
Chromosome location (bp)	192969 - 260745
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000177706 (version 83.38)
Entrez gene	56975
UniProt	Q8IXL6 (UniProt - Evidence at protein level)
neXtProt	NX_Q8IXL6
Antibodypedia	FAM20C antibodies

PROTEIN BROWSER

FAM20C-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FAM20C-001 ENSP00000322323 ENST00000313766	Q8IXL6 [Direct mapping] Extracellular serine/threonine protein kinase FAM20C Show all	Enzymes ENZYME proteins Transferases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001501 [skeletal system development] GO:0004674 [protein serine/threonine kinase activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005615 [extracellular space] GO:0005794 [Golgi apparatus] GO:0006468 [protein phosphorylation] GO:0030145 [manganese ion binding] GO:0030501 [positive regulation of bone mineralization] GO:0031214 [biomineral tissue development] GO:0036179 [osteoclast maturation] GO:0040036 [regulation of fibroblast growth factor receptor signaling pathway] GO:0045669 [positive regulation of osteoblast differentiation] GO:0051174 [regulation of phosphorus metabolic process] GO:0070062 [extracellular exosome] GO:0070166 [enamel mineralization] GO:0071895 [odontoblast differentiation] GO:0097187 [dentinogenesis] Show all	584 aa 66.2 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.