Cell atlas - PVRL3 - The Human Protein Atlas

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PVRL3

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Microtubule organizing center

Human cell
	Centrosome

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GENERAL INFORMATION
Gene name	PVRL3
Gene description	Poliovirus receptor-related 3
Protein class	CD markers Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	8
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the microtubule organizing center.
RNA cell category	Cell line enhanced (TIME)
Protein evidence	Evidence at protein level
Main location	Localized to the Microtubule organizing center (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA011038
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (TIME) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the microtubule organizing center.

Main location

Microtubule organizing center (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA011038	A-431	Microtubule organizing center
	HPA011038	U-2 OS	No staining
	HPA011038	U-251 MG	Microtubule organizing center

GENE INFORMATION
Gene name	PVRL3 (HGNC Symbol)
Synonyms	CD113, CDw113, DKFZP566B0846, nectin-3, PPR3, PVRR3
Description	Poliovirus receptor-related 3 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the nectin family of proteins, which function as adhesion molecules at adherens junctions. This family member interacts with other nectin-like proteins and with afadin, a filamentous actin-binding protein involved in the regulation of directional motility, cell proliferation and survival. This gene plays a role in ocular development involving the ciliary body. Mutations in this gene are believed to result in congenital ocular defects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]
Chromosome	3
Cytoband	q13.13
Chromosome location (bp)	111070071 - 111275563
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000177707 (version 83.38)
Entrez gene	25945
UniProt	Q9NQS3 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NQS3
Antibodypedia	PVRL3 antibodies

PROTEIN BROWSER

PVRL3-001	PVRL3-002	PVRL3-003	PVRL3-004	PVRL3-005	PVRL3-006	PVRL3-009	PVRL3-011

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PVRL3-001 ENSP00000321514 ENST00000319792	Q9NQS3 [Direct mapping] Nectin-3 Show all	CD markers MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004872 [receptor activity] GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0005913 [cell-cell adherens junction] GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules] GO:0007157 [heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules] GO:0008037 [cell recognition] GO:0034329 [cell junction assembly] GO:0034332 [adherens junction organization] GO:0042803 [protein homodimerization activity] GO:0043296 [apical junction complex] GO:0045211 [postsynaptic membrane] GO:0045216 [cell-cell junction organization] GO:0050839 [cell adhesion molecule binding] Show all	366 aa 39.7 kDa	No	0
PVRL3-002 ENSP00000418070 ENST00000485303	Q9NQS3 [Direct mapping] Nectin-3 Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002089 [lens morphogenesis in camera-type eye] GO:0004872 [receptor activity] GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0005911 [cell-cell junction] GO:0005913 [cell-cell adherens junction] GO:0007155 [cell adhesion] GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules] GO:0007157 [heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules] GO:0008037 [cell recognition] GO:0009566 [fertilization] GO:0016337 [single organismal cell-cell adhesion] GO:0034329 [cell junction assembly] GO:0034332 [adherens junction organization] GO:0042803 [protein homodimerization activity] GO:0043296 [apical junction complex] GO:0045211 [postsynaptic membrane] GO:0045216 [cell-cell junction organization] GO:0050839 [cell adhesion molecule binding] GO:0060042 [retina morphogenesis in camera-type eye] Show all	549 aa 61 kDa	No	1
PVRL3-003 ENSP00000420579 ENST00000493615	Q9NQS3 [Direct mapping] Nectin-3 Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004872 [receptor activity] GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0005913 [cell-cell adherens junction] GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules] GO:0007157 [heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules] GO:0008037 [cell recognition] GO:0034329 [cell junction assembly] GO:0034332 [adherens junction organization] GO:0042803 [protein homodimerization activity] GO:0043296 [apical junction complex] GO:0045211 [postsynaptic membrane] GO:0045216 [cell-cell junction organization] GO:0050839 [cell adhesion molecule binding] Show all	487 aa 54.4 kDa	No	1
PVRL3-004 ENSP00000419829 ENST00000485506	H7C5G5 [Direct mapping] Nectin-3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		31 aa 3.7 kDa	No	0
PVRL3-005 ENSP00000418327 ENST00000461477	C9J795 [Direct mapping] Nectin-3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	130 aa 13.9 kDa	No	0
PVRL3-006 ENSP00000418691 ENST00000491525	C9IZE6 [Direct mapping] Nectin-3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		17 aa 1.8 kDa	No	0
PVRL3-009 ENSP00000420479 ENST00000481766	C9JMW3 [Direct mapping] Nectin-3 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	168 aa 18.4 kDa	No	0
PVRL3-011 ENSP00000417572 ENST00000486596	H7C4L0 [Direct mapping] Nectin-3 Show all	MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	245 aa 26.3 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.