Tissue expression of KCNJ10 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	KCNJ10
Gene description	Potassium channel, inwardly rectifying subfamily J, member 10
Protein class	Disease related genes Plasma proteins Potential drug targets Predicted membrane proteins Voltage-gated ion channels
Predicted localization	Membrane
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Group enriched (cerebral cortex, kidney)
GTEx:	Group enriched (caudate, hippocampus, cerebral cortex, hypothalamus, cerebellum)
FANTOM5:	Group enriched (hippocampus, brain, cerebellum, caudate, kidney)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Group enriched (cerebral cortex, kidney)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Group enriched (caudate, hippocampus, cerebral cortex, hypothalamus, cerebellum)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Group enriched (hippocampus, brain, cerebellum, caudate, kidney)

GENE INFORMATION
Gene name	KCNJ10 (HGNC Symbol)
Synonyms	Kir1.2, Kir4.1
Description	Potassium channel, inwardly rectifying subfamily J, member 10 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the inward rectifier-type potassium channel family, characterized by having a greater tendency to allow potassium to flow into, rather than out of, a cell. The encoded protein may form a heterodimer with another potassium channel protein and may be responsible for the potassium buffering action of glial cells in the brain. Mutations in this gene have been associated with seizure susceptibility of common idiopathic generalized epilepsy syndromes. [provided by RefSeq, Jul 2008]
Chromosome	1
Cytoband	q23.2
Chromosome location (bp)	160037467 - 160070248
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000177807 (version 83.38)
Entrez gene	3766
UniProt	P78508 (UniProt - Evidence at protein level)
neXtProt	NX_P78508
Antibodypedia	KCNJ10 antibodies

PROTEIN BROWSER

KCNJ10-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
KCNJ10-001 ENSP00000357068 ENST00000368089	P78508 [Direct mapping] ATP-sensitive inward rectifier potassium channel 10 Show all	Voltage-gated ion channels Inwardly Rectifying Potassium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Show all	GO:0005242 [inward rectifier potassium channel activity] GO:0005267 [potassium channel activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006813 [potassium ion transport] GO:0007268 [synaptic transmission] GO:0007601 [visual perception] GO:0007628 [adult walking behavior] GO:0010107 [potassium ion import] GO:0014003 [oligodendrocyte development] GO:0015272 [ATP-activated inward rectifier potassium channel activity] GO:0016021 [integral component of membrane] GO:0016323 [basolateral plasma membrane] GO:0022010 [central nervous system myelination] GO:0034765 [regulation of ion transmembrane transport] GO:0042391 [regulation of membrane potential] GO:0048169 [regulation of long-term neuronal synaptic plasticity] GO:0051935 [glutamate reuptake] GO:0055075 [potassium ion homeostasis] GO:0060075 [regulation of resting membrane potential] Show all	379 aa 42.5 kDa	No	2