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A majority of cancer tissues showed weak to moderate cytoplasmic positivity. Additional nuclear positivity in a few cases. Additional membranous positivity was observed in colorectal and pancreatic cancers. A few cases of lymphomas showed strong immunoreactivity. Several cases of renal cancers were negative.
GENE INFORMATION
Gene name
UBE2N (HGNC Symbol)
Synonyms
MGC8489, UBC13, UbcH-ben
Description
Ubiquitin-conjugating enzyme E2N (HGNC Symbol)
Entrez gene summary
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. Studies in mouse suggest that this protein plays a role in DNA postreplication repair. [provided by RefSeq, Jul 2008]
P61088 [Direct mapping] Ubiquitin-conjugating enzyme E2 N V9HW41 [Target identity:100%; Query identity:100%] Epididymis secretory protein Li 71; Ubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast), isoform CRA_a
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Enzymes ENZYME proteins Transferases Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)