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RIC8A

CANCER ATLAS

Gene description

 RIC8 guanine nucleotide exchange factor A

Protein class

 Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA041491
CAB046012

GENE INFORMATION

Gene name

 RIC8A (HGNC Symbol)

Synonyms

 synembryn, synembryn-A

Description

 RIC8 guanine nucleotide exchange factor A (HGNC Symbol)

Entrez gene summary

Chromosome

 11

Cytoband

 p15.5

Chromosome location (bp)

 207511 - 215113

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000177963 (version 83.38)

Entrez gene

 60626

UniProt

 Q9NPQ8 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NPQ8

Antibodypedia

 RIC8A antibodies

PROTEIN BROWSER
RIC8A-001
RIC8A-002
RIC8A-003
RIC8A-006
RIC8A-008
RIC8A-009
RIC8A-011
RIC8A-016
RIC8A-017
RIC8A-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RIC8A-001
ENSP00000325941
ENST00000325207
Q9NPQ8 [Direct mapping]
Synembryn-A
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001701 [in utero embryonic development]
GO:0001944 [vasculature development]
GO:0001965 [G-protein alpha-subunit binding]
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005096 [GTPase activator activity]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007193 [adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway]
GO:0007369 [gastrulation]
GO:0008542 [visual learning]
GO:0009416 [response to light stimulus]
GO:0016020 [membrane]
GO:0042074 [cell migration involved in gastrulation]
GO:0043547 [positive regulation of GTPase activity]
GO:0070586 [cell-cell adhesion involved in gastrulation]
GO:0071711 [basement membrane organization]
Show all
 537 aa
60.4 kDa 		No 0
RIC8A-002
ENSP00000432008
ENST00000526104
Q9NPQ8 [Direct mapping]
Synembryn-A
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001965 [G-protein alpha-subunit binding]
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005096 [GTPase activator activity]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0043547 [positive regulation of GTPase activity]
Show all
 531 aa
59.7 kDa 		No 0
RIC8A-003
ENSP00000434833
ENST00000527696
Q9NPQ8 [Direct mapping]
Synembryn-A
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001965 [G-protein alpha-subunit binding]
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005096 [GTPase activator activity]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0043547 [positive regulation of GTPase activity]
Show all
 525 aa
58.9 kDa 		No 0
RIC8A-006
ENSP00000433968
ENST00000530889
E9PSI0 [Direct mapping]
Synembryn-A
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001965 [G-protein alpha-subunit binding]
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005096 [GTPase activator activity]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0043547 [positive regulation of GTPase activity]
Show all
 183 aa
20.7 kDa 		No 0
RIC8A-008
ENSP00000433009
ENST00000527468
E9PMP0 [Direct mapping]
Synembryn-A
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001965 [G-protein alpha-subunit binding]
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005096 [GTPase activator activity]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0043547 [positive regulation of GTPase activity]
Show all
 44 aa
4.9 kDa 		No 0
RIC8A-009
ENSP00000436610
ENST00000528357
E9PI04 [Direct mapping]
Synembryn-A
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001965 [G-protein alpha-subunit binding]
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005096 [GTPase activator activity]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0043547 [positive regulation of GTPase activity]
Show all
 148 aa
16.7 kDa 		No 0
RIC8A-011
ENSP00000436192
ENST00000527728
H0YEN0 [Direct mapping]
Synembryn-A
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001965 [G-protein alpha-subunit binding]
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005096 [GTPase activator activity]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0043547 [positive regulation of GTPase activity]
Show all
 287 aa
32.5 kDa 		No 0
RIC8A-016
ENSP00000434896
ENST00000524854
H0YE35 [Direct mapping]
Synembryn-A
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001965 [G-protein alpha-subunit binding]
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005096 [GTPase activator activity]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0043547 [positive regulation of GTPase activity]
Show all
 147 aa
16.1 kDa 		No 0
RIC8A-017
ENSP00000431163
ENST00000529275
H0YC88 [Direct mapping]
Synembryn-A
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001965 [G-protein alpha-subunit binding]
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005096 [GTPase activator activity]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0043547 [positive regulation of GTPase activity]
Show all
 147 aa
15.9 kDa 		No 0
RIC8A-201
ENSP00000487470
ENST00000626818
E9PLE5 [Direct mapping]
Synembryn-A
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001965 [G-protein alpha-subunit binding]
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005096 [GTPase activator activity]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0043547 [positive regulation of GTPase activity]
Show all
 52 aa
5.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.