Expression of NDUFAF3 in cancer - Summary

CANCER ATLAS

Gene description

NADH dehydrogenase (ubiquinone) complex I, assembly factor 3

Protein class

Disease related genes, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA035376	HPA035377

GENE INFORMATION
Gene name	NDUFAF3 (HGNC Symbol)
Synonyms	2P1, C3orf60, DKFZP564J0123, E3-3, MGC10527
Description	NADH dehydrogenase (ubiquinone) complex I, assembly factor 3 (HGNC Symbol)
Entrez gene summary	This gene encodes a mitochondrial complex I assembly protein that interacts with complex I subunits. Mutations in this gene cause mitochondrial complex I deficiency, a fatal neonatal disorder of the oxidative phosphorylation system. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2009]
Chromosome	3
Cytoband	p21.31
Chromosome location (bp)	49020459 - 49023495
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000178057 (version 83.38)
Entrez gene	25915
UniProt	Q9BU61 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BU61
Antibodypedia	NDUFAF3 antibodies

PROTEIN BROWSER

NDUFAF3-001	NDUFAF3-002	NDUFAF3-003	NDUFAF3-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NDUFAF3-001 ENSP00000323076 ENST00000326925	Q9BU61 [Direct mapping] NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3 Show all	Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0022904 [respiratory electron transport chain] GO:0032981 [mitochondrial respiratory chain complex I assembly] GO:0044237 [cellular metabolic process] GO:0044281 [small molecule metabolic process] Show all	184 aa 20.4 kDa	No	0
NDUFAF3-002 ENSP00000402465 ENST00000451378	Q9BU61 [Direct mapping] NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3 A4FU71 [Target identity:100%; Query identity:100%] C3orf60 protein; Chromosome 3 open reading frame 60, isoform CRA_c Show all	Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005743 [mitochondrial inner membrane] GO:0022904 [respiratory electron transport chain] GO:0032981 [mitochondrial respiratory chain complex I assembly] GO:0044237 [cellular metabolic process] GO:0044281 [small molecule metabolic process] Show all	127 aa 13.8 kDa	No	0
NDUFAF3-003 ENSP00000323003 ENST00000326912	Q9BU61 [Direct mapping] NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3 A4FU71 [Target identity:100%; Query identity:100%] C3orf60 protein; Chromosome 3 open reading frame 60, isoform CRA_c Show all	Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005743 [mitochondrial inner membrane] GO:0022904 [respiratory electron transport chain] GO:0032981 [mitochondrial respiratory chain complex I assembly] GO:0044237 [cellular metabolic process] GO:0044281 [small molecule metabolic process] Show all	127 aa 13.8 kDa	No	0
NDUFAF3-004 ENSP00000378843 ENST00000395458	Q9BU61 [Direct mapping] NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3 A4FU71 [Target identity:100%; Query identity:100%] C3orf60 protein; Chromosome 3 open reading frame 60, isoform CRA_c Show all	Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005743 [mitochondrial inner membrane] GO:0022904 [respiratory electron transport chain] GO:0032981 [mitochondrial respiratory chain complex I assembly] GO:0044237 [cellular metabolic process] GO:0044281 [small molecule metabolic process] Show all	127 aa 13.8 kDa	No	0