Cell atlas - NDUFV2 - The Human Protein Atlas

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NDUFV2

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TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Mitochondria

Human cell
	Mitochondria

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GENERAL INFORMATION
Gene name	NDUFV2
Gene description	NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the mitochondria.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Mitochondria (supported)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA077896
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the mitochondria.

Main location

Mitochondria (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA077896	CACO-2	No staining
	HPA077896	U-2 OS	Mitochondria	Intensity

GENE INFORMATION
Gene name	NDUFV2 (HGNC Symbol)
Synonyms	CI-24k
Description	NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa (HGNC Symbol)
Entrez gene summary	The NADH-ubiquinone oxidoreductase complex (complex I) of the mitochondrial respiratory chain catalyzes the transfer of electrons from NADH to ubiquinone, and consists of at least 43 subunits. The complex is located in the inner mitochondrial membrane. This gene encodes the 24 kDa subunit of complex I, and is involved in electron transfer. Mutations in this gene are implicated in Parkinson's disease, bipolar disorder, schizophrenia, and have been found in one case of early onset hypertrophic cardiomyopathy and encephalopathy. A non-transcribed pseudogene of this locus is found on chromosome 19. [provided by RefSeq, Oct 2009]
Chromosome	18
Cytoband	p11.22
Chromosome location (bp)	9102630 - 9134345
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000178127 (version 83.38)
Entrez gene	4729
UniProt	P19404 (UniProt - Evidence at protein level)
neXtProt	NX_P19404
Antibodypedia	NDUFV2 antibodies

PROTEIN BROWSER

NDUFV2-001	NDUFV2-002	NDUFV2-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NDUFV2-001 ENSP00000327268 ENST00000318388	P19404 [Direct mapping] NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial Show all	Enzymes ENZYME proteins Oxidoreductases Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0005747 [mitochondrial respiratory chain complex I] GO:0006120 [mitochondrial electron transport, NADH to ubiquinone] GO:0007399 [nervous system development] GO:0008137 [NADH dehydrogenase (ubiquinone) activity] GO:0009055 [electron carrier activity] GO:0016491 [oxidoreductase activity] GO:0022904 [respiratory electron transport chain] GO:0043209 [myelin sheath] GO:0044237 [cellular metabolic process] GO:0044281 [small molecule metabolic process] GO:0046872 [metal ion binding] GO:0048738 [cardiac muscle tissue development] GO:0051537 [2 iron, 2 sulfur cluster binding] GO:0055114 [oxidation-reduction process] Show all	249 aa 27.4 kDa	No	0
NDUFV2-002 ENSP00000382908 ENST00000400033	E7EPT4 [Direct mapping] NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0016491 [oxidoreductase activity] GO:0046872 [metal ion binding] GO:0051537 [2 iron, 2 sulfur cluster binding] GO:0055114 [oxidation-reduction process] Show all	252 aa 27.9 kDa	No	0
NDUFV2-003 ENSP00000464504 ENST00000497577	J3QS34 [Direct mapping] NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial Show all	Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		21 aa 2.4 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.