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LCORL

GENERAL INFORMATION

Gene name

 LCORL

Gene description

 Ligand dependent nuclear receptor corepressor-like

Protein class

 Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Mixed
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Nuclear and cytoplasmic expression in several tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Uncertain based on 2 antibodies.
HPA028794 , HPA028795
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 LCORL (HGNC Symbol)

Synonyms

 FLJ30696, MLR1

Description

 Ligand dependent nuclear receptor corepressor-like (HGNC Symbol)

Entrez gene summary

 This gene encodes a transcription factor that appears to function in spermatogenesis. Polymorphisms in this gene are associated with measures of skeletal frame size and adult height. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

Chromosome

 4

Cytoband

 p15.31

Chromosome location (bp)

 17841199 - 18021876

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000178177 (version 83.38)

Entrez gene

 254251

UniProt

 Q8N3X6 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8N3X6

Antibodypedia

 LCORL antibodies

PROTEIN BROWSER
LCORL-001
LCORL-002
LCORL-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
LCORL-001
ENSP00000317566
ENST00000326877
Q8N3X6 [Direct mapping]
Ligand-dependent nuclear receptor corepressor-like protein
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
Show all
 318 aa
35.4 kDa 		Yes 0
LCORL-002
ENSP00000371659
ENST00000382224
C9JI46 [Direct mapping]
Ligand-dependent nuclear receptor corepressor-like protein; Transcription factor MLR1, isoform CRA_b
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
Show all
 518 aa
57.5 kDa 		No 0
LCORL-201
ENSP00000371661
ENST00000382226
Q8N3X6 [Direct mapping]
Ligand-dependent nuclear receptor corepressor-like protein
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006366 [transcription from RNA polymerase II promoter]
Show all
 602 aa
67 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.