Expression of GEN1 in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

GEN1 Holliday junction 5' flap endonuclease

Protein class

Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA020078	HPA021141

GENE INFORMATION
Gene name	GEN1 (HGNC Symbol)
Synonyms	FLJ40869, Gen
Description	GEN1 Holliday junction 5' flap endonuclease (HGNC Symbol)
Entrez gene summary
Chromosome	2
Cytoband	p24.2
Chromosome location (bp)	17753858 - 17788941
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000178295 (version 83.38)
Entrez gene	348654
UniProt	Q17RS7 (UniProt - Evidence at protein level)
neXtProt	NX_Q17RS7
Antibodypedia	GEN1 antibodies

PROTEIN BROWSER

GEN1-001	GEN1-002	GEN1-003	GEN1-006	GEN1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GEN1-001 ENSP00000318977 ENST00000317402	Q17RS7 [Direct mapping] Flap endonuclease GEN homolog 1 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000724 [double-strand break repair via homologous recombination] GO:0003677 [DNA binding] GO:0003824 [catalytic activity] GO:0004518 [nuclease activity] GO:0005654 [nucleoplasm] GO:0005813 [centrosome] GO:0006281 [DNA repair] GO:0006302 [double-strand break repair] GO:0008821 [crossover junction endodeoxyribonuclease activity] GO:0010824 [regulation of centrosome duplication] GO:0046872 [metal ion binding] GO:0070062 [extracellular exosome] GO:0071139 [resolution of recombination intermediates] GO:0071140 [resolution of mitotic recombination intermediates] GO:0090267 [positive regulation of mitotic cell cycle spindle assembly checkpoint] GO:0090305 [nucleic acid phosphodiester bond hydrolysis] Show all	908 aa 102.9 kDa	No	0
GEN1-002 ENSP00000435143 ENST00000524465	E9PLG0 [Direct mapping] Flap endonuclease GEN homolog 1 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004518 [nuclease activity] GO:0006281 [DNA repair] GO:0090305 [nucleic acid phosphodiester bond hydrolysis] Show all	126 aa 14.4 kDa	No	0
GEN1-003 ENSP00000433180 ENST00000532257	E9PM30 [Direct mapping] Flap endonuclease GEN homolog 1 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004518 [nuclease activity] GO:0006281 [DNA repair] GO:0090305 [nucleic acid phosphodiester bond hydrolysis] Show all	93 aa 10.7 kDa	No	0
GEN1-006 ENSP00000481385 ENST00000534451	A0A087WXY3 [Direct mapping] Flap endonuclease GEN homolog 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0003824 [catalytic activity] GO:0004518 [nuclease activity] GO:0006281 [DNA repair] GO:0090305 [nucleic acid phosphodiester bond hydrolysis] Show all	129 aa 15.7 kDa	No	0
GEN1-201 ENSP00000370653 ENST00000381254	Q17RS7 [Direct mapping] Flap endonuclease GEN homolog 1 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000724 [double-strand break repair via homologous recombination] GO:0003677 [DNA binding] GO:0003824 [catalytic activity] GO:0004518 [nuclease activity] GO:0005654 [nucleoplasm] GO:0005813 [centrosome] GO:0006281 [DNA repair] GO:0006302 [double-strand break repair] GO:0008821 [crossover junction endodeoxyribonuclease activity] GO:0010824 [regulation of centrosome duplication] GO:0046872 [metal ion binding] GO:0070062 [extracellular exosome] GO:0071139 [resolution of recombination intermediates] GO:0071140 [resolution of mitotic recombination intermediates] GO:0090267 [positive regulation of mitotic cell cycle spindle assembly checkpoint] GO:0090305 [nucleic acid phosphodiester bond hydrolysis] Show all	908 aa 102.9 kDa	No	0