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HTR1A

GENERAL INFORMATION

Gene name

 HTR1A

Gene description

 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled

Protein class

 Disease related genes
FDA approved drug targets
G-protein coupled receptors
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Group enriched (ovary, cerebral cortex)
GTEx:Group enriched (hippocampus, cerebral cortex, hypothalamus)
FANTOM5:Tissue enriched (hippocampus)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in several tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining not consistent with RNA expression data. Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
HPA018073
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Ovary

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (ovary, cerebral cortex)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (hippocampus, cerebral cortex, hypothalamus)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (hippocampus)

GENE INFORMATION

Gene name

 HTR1A (HGNC Symbol)

Synonyms

 5-HT1A, ADRB2RL1, ADRBRL1

Description

 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled (HGNC Symbol)

Entrez gene summary

 This gene encodes a G protein-coupled receptor for 5-hydroxytryptamine (serotonin), and belongs to the 5-hydroxytryptamine receptor subfamily. Serotonin has been implicated in a number of physiologic processes and pathologic conditions. Inactivation of this gene in mice results in behavior consistent with an increased anxiety and stress response. Mutation in the promoter of this gene has been associated with menstrual cycle-dependent periodic fevers. [provided by RefSeq, Jun 2012]

Chromosome

 5

Cytoband

 q12.3

Chromosome location (bp)

 63960356 - 63962507

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000178394 (version 83.38)

Entrez gene

 3350

UniProt

 P08908 (UniProt - Evidence at protein level)

neXtProt

 NX_P08908

Antibodypedia

 HTR1A antibodies

PROTEIN BROWSER
HTR1A-001
HTR1A-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
HTR1A-001
ENSP00000316244
ENST00000323865
P08908 [Direct mapping]
5-hydroxytryptamine receptor 1A
Q5ZGX3 [Target identity:100%; Query identity:100%]
5-hydroxytryptamine (Serotonin) receptor 1A; 5-hydroxytryptamine receptor 1A
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G-protein coupled receptors
   GPCRs excl olfactory receptors
   Serotonin receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Small molecule drugs
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GO:0001662 [behavioral fear response]
GO:0004930 [G-protein coupled receptor activity]
GO:0004993 [serotonin receptor activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007198 [adenylate cyclase-inhibiting serotonin receptor signaling pathway]
GO:0007210 [serotonin receptor signaling pathway]
GO:0008283 [cell proliferation]
GO:0008284 [positive regulation of cell proliferation]
GO:0014062 [regulation of serotonin secretion]
GO:0016021 [integral component of membrane]
GO:0035640 [exploration behavior]
GO:0042053 [regulation of dopamine metabolic process]
GO:0042310 [vasoconstriction]
GO:0042428 [serotonin metabolic process]
GO:0046883 [regulation of hormone secretion]
GO:0050795 [regulation of behavior]
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 422 aa
46.1 kDa 		No 7
HTR1A-003
ENSP00000423433
ENST00000506598
D6RA34 [Direct mapping]
5-hydroxytryptamine receptor 1A
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Predicted intracellular proteins
Show all
GO:0004993 [serotonin receptor activity]
GO:0005887 [integral component of plasma membrane]
GO:0007210 [serotonin receptor signaling pathway]
GO:0008283 [cell proliferation]
GO:0042310 [vasoconstriction]
GO:0046883 [regulation of hormone secretion]
GO:0050795 [regulation of behavior]
Show all
 42 aa
4.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.