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UCN3

CANCER ATLAS

Gene description

 Urocortin 3

Protein class

 Predicted secreted proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA038281

GENE INFORMATION

Gene name

 UCN3 (HGNC Symbol)

Synonyms

 SPC, UCNIII

Description

 Urocortin 3 (HGNC Symbol)

Entrez gene summary

 This gene is a member of the sauvagine/corticotropin-releasing factor/urotensin I family. It is structurally related to the corticotropin-releasing factor (CRF) gene and the encoded product is an endogenous ligand for CRF type 2 receptors. In the brain it may be responsible for the effects of stress on appetite. In spite of the gene family name similarity, the product of this gene has no sequence similarity to urotensin II. [provided by RefSeq, Jul 2008]

Chromosome

 10

Cytoband

 p15.1

Chromosome location (bp)

 5365009 - 5374692

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000178473 (version 83.38)

Entrez gene

 114131

UniProt

 Q969E3 (UniProt - Evidence at protein level)

neXtProt

 NX_Q969E3

Antibodypedia

 UCN3 antibodies

PROTEIN BROWSER
UCN3-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
UCN3-001
ENSP00000369798
ENST00000380433
Q969E3 [Direct mapping]
Urocortin-3
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   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Kim et al 2014)
Show all
GO:0001664 [G-protein coupled receptor binding]
GO:0005179 [hormone activity]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0007189 [adenylate cyclase-activating G-protein coupled receptor signaling pathway]
GO:0007586 [digestion]
GO:0031669 [cellular response to nutrient levels]
GO:0051431 [corticotropin-releasing hormone receptor 2 binding]
Show all
 161 aa
18 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.