Tissue expression of AMBN - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	AMBN
Gene description	Ameloblastin (enamel matrix protein)
Protein class	Disease related genes Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Not detected
GTEx:	Tissue enriched (caudate)
FANTOM5:	Tissue enriched (caudate)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Not detected
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (caudate)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (caudate)

GENE INFORMATION
Gene name	AMBN
Synonyms
Description	Ameloblastin (enamel matrix protein) (HGNC Symbol)
Entrez gene summary	This gene encodes the nonamelogenin enamel matrix protein ameloblastin. The encoded protein may be important in enamel matrix formation and mineralization. This gene is located in the calcium-binding phosphoprotein gene cluster on chromosome 4. Mutations in this gene may be associated with dentinogenesis imperfect and autosomal dominant amylogenesis imperfect. [provided by RefSeq, Aug 2011]
Chromosome	4
Cytoband	q13.3
Chromosome location (bp)	70592256 - 70607288
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000178522 (version 83.38)
Entrez gene	258
UniProt	Q9NP70 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9NP70
Antibodypedia	AMBN antibodies

PROTEIN BROWSER

AMBN-001	AMBN-002	AMBN-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
AMBN-001 ENSP00000313809 ENST00000322937	Q9NP70 [Direct mapping] Ameloblastin Q546D7 [Target identity:100%; Query identity:100%] Ameloblastin; cDNA, FLJ95827, Homo sapiens ameloblastin, enamel matrix protein (AMBN), mRNA Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes Protein evidence (Kim et al 2014) Show all	GO:0005578 [proteinaceous extracellular matrix] GO:0007155 [cell adhesion] GO:0008083 [growth factor activity] GO:0008283 [cell proliferation] GO:0030345 [structural constituent of tooth enamel] GO:0031214 [biomineral tissue development] GO:0042475 [odontogenesis of dentin-containing tooth] Show all	447 aa 48.3 kDa	Yes	0
AMBN-002 ENSP00000391234 ENST00000449493	Q9NP70 [Direct mapping] Ameloblastin Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes Show all	GO:0005578 [proteinaceous extracellular matrix] GO:0007155 [cell adhesion] GO:0008083 [growth factor activity] GO:0008283 [cell proliferation] GO:0030345 [structural constituent of tooth enamel] GO:0031214 [biomineral tissue development] GO:0042475 [odontogenesis of dentin-containing tooth] Show all	432 aa 46.6 kDa	Yes	0
AMBN-201 ENSP00000479096 ENST00000613447	A0A087WV21 [Direct mapping] Ameloblastin Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0030345 [structural constituent of tooth enamel] GO:0042475 [odontogenesis of dentin-containing tooth] Show all	446 aa 48.3 kDa	Yes	0