Fields »
ABOUT
HELP
BLOG
CD28

GENERAL INFORMATION

Gene name

 CD28

Gene description

 CD28 molecule

Protein class

 CD markers
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (lymph node, placenta)
GTEx:Tissue enhanced (spleen, small intestine)
FANTOM5:Tissue enhanced (tonsil)

Protein evidence

 Evidence at protein level

Protein expression

 Selective cytoplasmic expression in subsets of immune cells.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data. Pending external verification.

Reliability score

 Supported based on 1 antibody.
HPA070003
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Prostate
N/A
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Tonsil

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (lymph node, placenta)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (spleen, small intestine)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (tonsil)

GENE INFORMATION

Gene name

 CD28

Synonyms

Description

 CD28 molecule (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is essential for T-cell proliferation and survival, cytokine production, and T-helper type-2 development. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2011]

Chromosome

 2

Cytoband

 q33.2

Chromosome location (bp)

 203706475 - 203738912

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000178562 (version 83.38)

Entrez gene

 940

UniProt

 P10747 (UniProt - Evidence at protein level)

neXtProt

 NX_P10747

Antibodypedia

 CD28 antibodies

PROTEIN BROWSER
CD28-001
CD28-002
CD28-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CD28-001
ENSP00000324890
ENST00000324106
P10747 [Direct mapping]
T-cell-specific surface glycoprotein CD28
Show all
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001772 [immunological synapse]
GO:0002020 [protease binding]
GO:0002863 [positive regulation of inflammatory response to antigenic stimulus]
GO:0005070 [SH3/SH2 adaptor activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006959 [humoral immune response]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0009897 [external side of plasma membrane]
GO:0010628 [positive regulation of gene expression]
GO:0010629 [negative regulation of gene expression]
GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling]
GO:0015026 [coreceptor activity]
GO:0016032 [viral process]
GO:0019901 [protein kinase binding]
GO:0031295 [T cell costimulation]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042089 [cytokine biosynthetic process]
GO:0042102 [positive regulation of T cell proliferation]
GO:0042802 [identical protein binding]
GO:0045060 [negative thymic T cell selection]
GO:0045066 [regulatory T cell differentiation]
GO:0045070 [positive regulation of viral genome replication]
GO:0045086 [positive regulation of interleukin-2 biosynthetic process]
GO:0045087 [innate immune response]
GO:0045589 [regulation of regulatory T cell differentiation]
GO:0045727 [positive regulation of translation]
GO:0045840 [positive regulation of mitotic nuclear division]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046641 [positive regulation of alpha-beta T cell proliferation]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0048304 [positive regulation of isotype switching to IgG isotypes]
GO:0050690 [regulation of defense response to virus by virus]
GO:0050852 [T cell receptor signaling pathway]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0097190 [apoptotic signaling pathway]
Show all
 220 aa
25.1 kDa 		Yes 1
CD28-002
ENSP00000393648
ENST00000458610
P10747 [Direct mapping]
T-cell-specific surface glycoprotein CD28
Show all
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002020 [protease binding]
GO:0005070 [SH3/SH2 adaptor activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006959 [humoral immune response]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0009897 [external side of plasma membrane]
GO:0010628 [positive regulation of gene expression]
GO:0010629 [negative regulation of gene expression]
GO:0015026 [coreceptor activity]
GO:0016032 [viral process]
GO:0031295 [T cell costimulation]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042089 [cytokine biosynthetic process]
GO:0042102 [positive regulation of T cell proliferation]
GO:0042802 [identical protein binding]
GO:0045066 [regulatory T cell differentiation]
GO:0045070 [positive regulation of viral genome replication]
GO:0045086 [positive regulation of interleukin-2 biosynthetic process]
GO:0045087 [innate immune response]
GO:0045727 [positive regulation of translation]
GO:0045840 [positive regulation of mitotic nuclear division]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0050690 [regulation of defense response to virus by virus]
Show all
 234 aa
26.2 kDa 		Yes 1
CD28-201
ENSP00000363605
ENST00000374481
P10747 [Direct mapping]
T-cell-specific surface glycoprotein CD28
Show all
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002020 [protease binding]
GO:0005070 [SH3/SH2 adaptor activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006959 [humoral immune response]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0009897 [external side of plasma membrane]
GO:0010628 [positive regulation of gene expression]
GO:0010629 [negative regulation of gene expression]
GO:0015026 [coreceptor activity]
GO:0016032 [viral process]
GO:0031295 [T cell costimulation]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042089 [cytokine biosynthetic process]
GO:0042102 [positive regulation of T cell proliferation]
GO:0042802 [identical protein binding]
GO:0045066 [regulatory T cell differentiation]
GO:0045070 [positive regulation of viral genome replication]
GO:0045086 [positive regulation of interleukin-2 biosynthetic process]
GO:0045087 [innate immune response]
GO:0045727 [positive regulation of translation]
GO:0045840 [positive regulation of mitotic nuclear division]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0050690 [regulation of defense response to virus by virus]
Show all
 101 aa
11.5 kDa 		Yes 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.