Expression of PARP10 in cancer - Summary

CANCER ATLAS

Gene description

Poly (ADP-ribose) polymerase family, member 10

Protein class

Enzymes, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA028122

GENE INFORMATION
Gene name	PARP10 (HGNC Symbol)
Synonyms	FLJ14464
Description	Poly (ADP-ribose) polymerase family, member 10 (HGNC Symbol)
Entrez gene summary	Poly(ADP-ribose) polymerases (PARPs), such as PARP10, regulate gene transcription by altering chromatin organization by adding ADP-ribose to histones. PARPs can also function as transcriptional cofactors (Yu et al., 2005 [PubMed 15674325]).[supplied by OMIM, Mar 2008]
Chromosome	8
Cytoband	q24.3
Chromosome location (bp)	143977153 - 144012772
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000178685 (version 83.38)
Entrez gene	84875
UniProt	Q53GL7 (UniProt - Evidence at protein level)
neXtProt	NX_Q53GL7
Antibodypedia	PARP10 antibodies

PROTEIN BROWSER

PARP10-001	PARP10-004	PARP10-005	PARP10-008	PARP10-011	PARP10-012	PARP10-013	PARP10-014	PARP10-015	PARP10-018	PARP10-019	PARP10-020	PARP10-021	PARP10-022	PARP10-024

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PARP10-001 ENSP00000325618 ENST00000313028	Q53GL7 [Direct mapping] Poly [ADP-ribose] polymerase 10 Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003950 [NAD+ ADP-ribosyltransferase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005794 [Golgi apparatus] GO:0006471 [protein ADP-ribosylation] GO:0010629 [negative regulation of gene expression] GO:0010847 [regulation of chromatin assembly] GO:0032088 [negative regulation of NF-kappaB transcription factor activity] GO:0033159 [negative regulation of protein import into nucleus, translocation] GO:0045071 [negative regulation of viral genome replication] GO:0048147 [negative regulation of fibroblast proliferation] GO:0070212 [protein poly-ADP-ribosylation] GO:0070213 [protein auto-ADP-ribosylation] GO:0070530 [K63-linked polyubiquitin binding] GO:1900045 [negative regulation of protein K63-linked ubiquitination] Show all	1025 aa 110 kDa	No	0
PARP10-004 ENSP00000431620 ENST00000524918	E9PK67 [Direct mapping] Poly [ADP-ribose] polymerase 10 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003950 [NAD+ ADP-ribosyltransferase activity] GO:0005654 [nucleoplasm] GO:0005794 [Golgi apparatus] GO:0008152 [metabolic process] Show all	1016 aa 109.1 kDa	No	0
PARP10-005 ENSP00000314320 ENST00000313059	F8W8G7 [Direct mapping] Poly [ADP-ribose] polymerase 10 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005654 [nucleoplasm] GO:0005794 [Golgi apparatus] Show all	339 aa 35.4 kDa	No	0
PARP10-008 ENSP00000434776 ENST00000525773	E9PNI7 [Direct mapping] Poly [ADP-ribose] polymerase 10 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003950 [NAD+ ADP-ribosyltransferase activity] GO:0005654 [nucleoplasm] GO:0005794 [Golgi apparatus] GO:0008152 [metabolic process] Show all	1037 aa 111.4 kDa	No	0
PARP10-011 ENSP00000435161 ENST00000532311	E9PLE8 [Direct mapping] Poly [ADP-ribose] polymerase 10 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		83 aa 8.9 kDa	No	0
PARP10-012 ENSP00000434005 ENST00000528914	E9PSE7 [Direct mapping] Poly [ADP-ribose] polymerase 10 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] Show all	136 aa 14.5 kDa	No	0
PARP10-013 ENSP00000431250 ENST00000528136	E9PM86 [Direct mapping] Poly [ADP-ribose] polymerase 10 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] Show all	129 aa 13.7 kDa	No	0
PARP10-014 ENSP00000436301 ENST00000525879	E9PPV8 [Direct mapping] Poly [ADP-ribose] polymerase 10 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		178 aa 19 kDa	No	0
PARP10-015 ENSP00000431818 ENST00000528625	E9PJI2 [Direct mapping] Poly [ADP-ribose] polymerase 10 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		172 aa 18.3 kDa	No	0
PARP10-018 ENSP00000434411 ENST00000529311	E9PQQ6 [Direct mapping] Poly [ADP-ribose] polymerase 10 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		106 aa 11.3 kDa	No	0
PARP10-019 ENSP00000435793 ENST00000525486	E9PIK9 [Direct mapping] Poly [ADP-ribose] polymerase 10 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] Show all	146 aa 15.5 kDa	No	0
PARP10-020 ENSP00000432204 ENST00000531537	E9PIA6 [Direct mapping] Poly [ADP-ribose] polymerase 10 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] Show all	144 aa 15.4 kDa	No	0
PARP10-021 ENSP00000436697 ENST00000529842	E9PIA6 [Direct mapping] Poly [ADP-ribose] polymerase 10 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] Show all	144 aa 15.4 kDa	No	0
PARP10-022 ENSP00000433990 ENST00000531707	E9PSG8 [Direct mapping] Poly [ADP-ribose] polymerase 10 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		81 aa 8.7 kDa	No	0
PARP10-024 ENSP00000436333 ENST00000530478	E9PPU2 [Direct mapping] Poly [ADP-ribose] polymerase 10 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		89 aa 9.5 kDa	No	0