Expression of DHFRL1 in cancer - Summary

CANCER ATLAS

Gene description

Dihydrofolate reductase-like 1

Protein class

Enzymes, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA051465

GENE INFORMATION
Gene name	DHFRL1 (HGNC Symbol)
Synonyms	DHFRP4, FLJ16119
Description	Dihydrofolate reductase-like 1 (HGNC Symbol)
Entrez gene summary
Chromosome	3
Cytoband	q11.2
Chromosome location (bp)	94047836 - 94063389
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000178700 (version 83.38)
Entrez gene	200895
UniProt	Q86XF0 (UniProt - Evidence at protein level)
neXtProt	NX_Q86XF0
Antibodypedia	DHFRL1 antibodies

PROTEIN BROWSER

DHFRL1-001	DHFRL1-002	DHFRL1-004	DHFRL1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DHFRL1-001 ENSP00000377768 ENST00000394221	Q86XF0 [Direct mapping] Dihydrofolate reductase, mitochondrial Show all	Enzymes ENZYME proteins Oxidoreductases SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Show all	GO:0003729 [mRNA binding] GO:0004146 [dihydrofolate reductase activity] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0005759 [mitochondrial matrix] GO:0006545 [glycine biosynthetic process] GO:0006730 [one-carbon metabolic process] GO:0009165 [nucleotide biosynthetic process] GO:0046105 [thymidine biosynthetic process] GO:0046653 [tetrahydrofolate metabolic process] GO:0046654 [tetrahydrofolate biosynthetic process] GO:0050661 [NADP binding] GO:0055114 [oxidation-reduction process] Show all	187 aa 21.6 kDa	No	0
DHFRL1-002 ENSP00000319170 ENST00000314636	Q86XF0 [Direct mapping] Dihydrofolate reductase, mitochondrial Show all	Enzymes ENZYME proteins Oxidoreductases SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Show all	GO:0003729 [mRNA binding] GO:0004146 [dihydrofolate reductase activity] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0005759 [mitochondrial matrix] GO:0006545 [glycine biosynthetic process] GO:0006730 [one-carbon metabolic process] GO:0009165 [nucleotide biosynthetic process] GO:0046105 [thymidine biosynthetic process] GO:0046653 [tetrahydrofolate metabolic process] GO:0046654 [tetrahydrofolate biosynthetic process] GO:0050661 [NADP binding] GO:0055114 [oxidation-reduction process] Show all	187 aa 21.6 kDa	No	0
DHFRL1-004 ENSP00000420810 ENST00000496983	C9JJ68 [Direct mapping] Dihydrofolate reductase, mitochondrial Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Show all	GO:0004146 [dihydrofolate reductase activity] GO:0006545 [glycine biosynthetic process] GO:0009165 [nucleotide biosynthetic process] GO:0050661 [NADP binding] GO:0055114 [oxidation-reduction process] Show all	114 aa 13.2 kDa	No	0
DHFRL1-201 ENSP00000480823 ENST00000619045	Q86XF0 [Direct mapping] Dihydrofolate reductase, mitochondrial Show all	Enzymes ENZYME proteins Oxidoreductases SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Show all	GO:0003729 [mRNA binding] GO:0004146 [dihydrofolate reductase activity] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0005759 [mitochondrial matrix] GO:0006545 [glycine biosynthetic process] GO:0006730 [one-carbon metabolic process] GO:0009165 [nucleotide biosynthetic process] GO:0046105 [thymidine biosynthetic process] GO:0046653 [tetrahydrofolate metabolic process] GO:0046654 [tetrahydrofolate biosynthetic process] GO:0050661 [NADP binding] GO:0055114 [oxidation-reduction process] Show all	187 aa 21.6 kDa	No	0