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MPI

CANCER ATLAS

Gene description

 Mannose phosphate isomerase

Protein class

 Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA007200

GENE INFORMATION

Gene name

 MPI

Synonyms

Description

 Mannose phosphate isomerase (HGNC Symbol)

Entrez gene summary

 Phosphomannose isomerase catalyzes the interconversion of fructose-6-phosphate and mannose-6-phosphate and plays a critical role in maintaining the supply of D-mannose derivatives, which are required for most glycosylation reactions. Mutations in the MPI gene were found in patients with carbohydrate-deficient glycoprotein syndrome, type Ib. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

Chromosome

 15

Cytoband

Chromosome location (bp)

 74890005 - 74902219

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000178802 (version 83.38)

Entrez gene

 4351

UniProt

 P34949 (UniProt - Evidence at protein level)

neXtProt

 NX_P34949

Antibodypedia

 MPI antibodies

PROTEIN BROWSER
«
MPI-001
MPI-002
MPI-003
MPI-004
MPI-005
MPI-006
MPI-008
MPI-010
MPI-012
MPI-013
MPI-014
MPI-015
MPI-018
MPI-019
MPI-021
MPI-022
MPI-023
MPI-024
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MPI-001
ENSP00000318318
ENST00000352410
P34949 [Direct mapping]
Mannose-6-phosphate isomerase
Show all
Enzymes
   ENZYME proteins
   Isomerase
   MEMSAT3 predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004476 [mannose-6-phosphate isomerase activity]
GO:0005829 [cytosol]
GO:0005975 [carbohydrate metabolic process]
GO:0006488 [dolichol-linked oligosaccharide biosynthetic process]
GO:0008270 [zinc ion binding]
GO:0009298 [GDP-mannose biosynthetic process]
GO:0018279 [protein N-linked glycosylation via asparagine]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0061611 [mannose to fructose-6-phosphate metabolic process]
GO:0070062 [extracellular exosome]
Show all
 423 aa
46.7 kDa 		No 0
MPI-002
ENSP00000440447
ENST00000535694
F5GX71 [Direct mapping]
Mannose-6-phosphate isomerase
Show all
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004476 [mannose-6-phosphate isomerase activity]
GO:0005975 [carbohydrate metabolic process]
GO:0008270 [zinc ion binding]
GO:0009298 [GDP-mannose biosynthetic process]
Show all
 373 aa
41.2 kDa 		No 0
MPI-003
ENSP00000455405
ENST00000566377
H3BPP3 [Direct mapping]
Mannose-6-phosphate isomerase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004476 [mannose-6-phosphate isomerase activity]
GO:0005975 [carbohydrate metabolic process]
GO:0008270 [zinc ion binding]
GO:0009298 [GDP-mannose biosynthetic process]
Show all
 287 aa
31.9 kDa 		No 0
MPI-004
ENSP00000454312
ENST00000564003
B4DYB8 [Direct mapping]
Mannose-6-phosphate isomerase; cDNA FLJ54812, moderately similar to Mannose-6-phosphate isomerase (EC 5.3.1.8)
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004476 [mannose-6-phosphate isomerase activity]
GO:0005975 [carbohydrate metabolic process]
GO:0008270 [zinc ion binding]
GO:0009298 [GDP-mannose biosynthetic process]
Show all
 228 aa
25.4 kDa 		No 0
MPI-005
ENSP00000457885
ENST00000563422
H3BUZ9 [Direct mapping]
Mannose-6-phosphate isomerase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004476 [mannose-6-phosphate isomerase activity]
GO:0005975 [carbohydrate metabolic process]
GO:0008270 [zinc ion binding]
GO:0009298 [GDP-mannose biosynthetic process]
Show all
 339 aa
37.7 kDa 		No 0
MPI-006
ENSP00000455241
ENST00000563786
H3BPB8 [Direct mapping]
Mannose-6-phosphate isomerase
Show all
   MEMSAT3 predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004476 [mannose-6-phosphate isomerase activity]
GO:0005975 [carbohydrate metabolic process]
GO:0008270 [zinc ion binding]
GO:0009298 [GDP-mannose biosynthetic process]
Show all
 403 aa
44.4 kDa 		No 0
MPI-008
ENSP00000318192
ENST00000323744
P34949 [Direct mapping]
Mannose-6-phosphate isomerase
Show all
Enzymes
   ENZYME proteins
   Isomerase
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004476 [mannose-6-phosphate isomerase activity]
GO:0005829 [cytosol]
GO:0005975 [carbohydrate metabolic process]
GO:0006488 [dolichol-linked oligosaccharide biosynthetic process]
GO:0008270 [zinc ion binding]
GO:0009298 [GDP-mannose biosynthetic process]
GO:0018279 [protein N-linked glycosylation via asparagine]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0070062 [extracellular exosome]
Show all
 362 aa
39.8 kDa 		No 0
MPI-010
ENSP00000454622
ENST00000569233
H3BN01 [Direct mapping]
Mannose-6-phosphate isomerase
Show all
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004476 [mannose-6-phosphate isomerase activity]
GO:0005975 [carbohydrate metabolic process]
GO:0008270 [zinc ion binding]
GO:0009298 [GDP-mannose biosynthetic process]
Show all
 174 aa
19.4 kDa 		No 0
MPI-012
ENSP00000455477
ENST00000567570
H3BPU7 [Direct mapping]
Mannose-6-phosphate isomerase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004476 [mannose-6-phosphate isomerase activity]
GO:0005975 [carbohydrate metabolic process]
GO:0008270 [zinc ion binding]
GO:0009298 [GDP-mannose biosynthetic process]
Show all
 119 aa
13.2 kDa 		No 0
MPI-013
ENSP00000457020
ENST00000562606
H3BT48 [Direct mapping]
Mannose-6-phosphate isomerase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004476 [mannose-6-phosphate isomerase activity]
GO:0005975 [carbohydrate metabolic process]
GO:0008270 [zinc ion binding]
GO:0009298 [GDP-mannose biosynthetic process]
Show all
 319 aa
35.5 kDa 		No 0
MPI-014
ENSP00000455161
ENST00000569931
H3BP57 [Direct mapping]
Mannose-6-phosphate isomerase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004476 [mannose-6-phosphate isomerase activity]
GO:0005975 [carbohydrate metabolic process]
GO:0008270 [zinc ion binding]
GO:0009298 [GDP-mannose biosynthetic process]
Show all
 288 aa
31.9 kDa 		No 0
MPI-015
ENSP00000454619
ENST00000565576
H3BMZ9 [Direct mapping]
Mannose-6-phosphate isomerase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004476 [mannose-6-phosphate isomerase activity]
GO:0005975 [carbohydrate metabolic process]
GO:0008270 [zinc ion binding]
GO:0009298 [GDP-mannose biosynthetic process]
Show all
 264 aa
29.3 kDa 		No 0
MPI-018
ENSP00000457494
ENST00000568907
H3BU66 [Direct mapping]
Mannose-6-phosphate isomerase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004476 [mannose-6-phosphate isomerase activity]
GO:0005975 [carbohydrate metabolic process]
GO:0008270 [zinc ion binding]
GO:0009298 [GDP-mannose biosynthetic process]
Show all
 168 aa
18.6 kDa 		No 0
MPI-019
ENSP00000455065
ENST00000568828
H3BNY8 [Direct mapping]
Mannose-6-phosphate isomerase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004476 [mannose-6-phosphate isomerase activity]
GO:0005975 [carbohydrate metabolic process]
GO:0008270 [zinc ion binding]
GO:0009298 [GDP-mannose biosynthetic process]
Show all
 185 aa
20.4 kDa 		No 0
MPI-021
ENSP00000455972
ENST00000567132
H3BQX0 [Direct mapping]
Mannose-6-phosphate isomerase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004476 [mannose-6-phosphate isomerase activity]
GO:0005975 [carbohydrate metabolic process]
GO:0008270 [zinc ion binding]
GO:0009298 [GDP-mannose biosynthetic process]
Show all
 176 aa
19.5 kDa 		No 0
MPI-022
ENSP00000455383
ENST00000564633
H3BPM5 [Direct mapping]
Mannose-6-phosphate isomerase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004476 [mannose-6-phosphate isomerase activity]
GO:0005975 [carbohydrate metabolic process]
GO:0008270 [zinc ion binding]
GO:0009298 [GDP-mannose biosynthetic process]
Show all
 173 aa
19.1 kDa 		No 0
MPI-023
ENSP00000457013
ENST00000567177
H3BT46 [Direct mapping]
Mannose-6-phosphate isomerase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004476 [mannose-6-phosphate isomerase activity]
GO:0005975 [carbohydrate metabolic process]
GO:0008270 [zinc ion binding]
GO:0009298 [GDP-mannose biosynthetic process]
Show all
 213 aa
23.7 kDa 		No 0
MPI-024
ENSP00000457619
ENST00000562800
H3BUG1 [Direct mapping]
Mannose-6-phosphate isomerase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004476 [mannose-6-phosphate isomerase activity]
GO:0005975 [carbohydrate metabolic process]
GO:0008270 [zinc ion binding]
GO:0009298 [GDP-mannose biosynthetic process]
Show all
 125 aa
13.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.