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Most cancer tissues showed moderate to strong nuclear positivity. Several testicular cancers, renal cell carcinomas along with few lymphomas and gliomas were negative.
Colorectal cancer and the majority of breast, ovarian, gastric and pancreatic cancers along with several cervical and urothelial cancers showed moderate to strong nuclear and/or cytoplasmic staining. Other cancer tissues were in general weakly stained or negative.
Most cancer tissues showed moderate to strong nuclear positivity. Testicular cancers, several renal cell carcinomas, gliomas and liver cancers were weakly stained or negative.
GENE INFORMATION
Gene name
ZBTB7A (HGNC Symbol)
Synonyms
DKFZp547O146, FBI-1, LRF, pokemon, ZBTB7, ZNF857A
Description
Zinc finger and BTB domain containing 7A (HGNC Symbol)
O95365 [Direct mapping] Zinc finger and BTB domain-containing protein 7A
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Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0001078 [transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0007275 [multicellular organismal development] GO:0030154 [cell differentiation] GO:0035035 [histone acetyltransferase binding] GO:0045670 [regulation of osteoclast differentiation] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0046872 [metal ion binding]
