Cell atlas - TRIML2 - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

TRIML2

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Plasma membrane

Human cell
	Cytosol
	Plasma Membrane

Please wait until image is loaded before changing channels

GENERAL INFORMATION
Gene name	TRIML2
Gene description	Tripartite motif family-like 2
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the plasma membrane & cytosol.
RNA cell category	Group enriched (NTERA-2, A549, BEWO, hTCEpi, U-2 OS)
Protein evidence	Evidence at protein level
Main location	Localized to the Plasma membrane (approved), Cytosol (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA043838
	SHOW MORE

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Group enriched (NTERA-2, A549, BEWO, hTCEpi, U-2 OS) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the plasma membrane & cytosol.

Main location

Plasma membrane (approved), Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA043838	A-431	Nucleoplasm
			Plasma membrane
			Cytosol
	HPA043838	U-2 OS	Plasma membrane
	HPA043838	U-2 OS	Cytosol
	HPA043838	U-251 MG	Plasma membrane
	HPA043838	U-251 MG	Cytosol

GENE INFORMATION
Gene name	TRIML2 (HGNC Symbol)
Synonyms	FLJ25801, SPRYD6
Description	Tripartite motif family-like 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the tri-partite motif (TRIM) family of proteins. This protein may be regulated by the tumor suppressor p53 and may regulate p53 through the enhancement of p53 SUMOylation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
Chromosome	4
Cytoband	q35.2
Chromosome location (bp)	188091273 - 188109603
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000179046 (version 83.38)
Entrez gene	205860
UniProt	Q8N7C3 (UniProt - Evidence at transcript level)
neXtProt	NX_Q8N7C3
Antibodypedia	TRIML2 antibodies

PROTEIN BROWSER

TRIML2-001	TRIML2-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TRIML2-001 ENSP00000422581 ENST00000512729	Q8N7C3 [Direct mapping] Probable E3 ubiquitin-protein ligase TRIML2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0008270 [zinc ion binding] GO:0010033 [response to organic substance] GO:0016567 [protein ubiquitination] GO:0016874 [ligase activity] GO:0032526 [response to retinoic acid] Show all	437 aa 49.9 kDa	No	0
TRIML2-003 ENSP00000317498 ENST00000326754	B7ZLC3 [Direct mapping] Probable E3 ubiquitin-protein ligase TRIML2; TRIML2 protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	422 aa 48.1 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.