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DPM3

CANCER ATLAS

Gene description

 Dolichyl-phosphate mannosyltransferase polypeptide 3

Protein class

 Disease related genes, Predicted membrane proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA014667

GENE INFORMATION

Gene name

 DPM3 (HGNC Symbol)

Synonyms

 MGC125904, MGC125905, MGC34275

Description

 Dolichyl-phosphate mannosyltransferase polypeptide 3 (HGNC Symbol)

Entrez gene summary

 Dolichol-phosphate mannose (Dol-P-Man) serves as a donor of mannosyl residues on the lumenal side of the endoplasmic reticulum (ER). Lack of Dol-P-Man results in defective surface expression of GPI-anchored proteins. Dol-P-Man is synthesized from GDP-mannose and dolichol-phosphate on the cytosolic side of the ER by the enzyme dolichyl-phosphate mannosyltransferase. The protein encoded by this gene is a subunit of dolichyl-phosphate mannosyltransferase and acts as a stabilizer subunit of the dolichyl-phosphate mannosyltransferase complex. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 q22

Chromosome location (bp)

 155139891 - 155140595

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000179085 (version 83.38)

Entrez gene

 54344

UniProt

 Q9P2X0 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9P2X0

Antibodypedia

 DPM3 antibodies

PROTEIN BROWSER
DPM3-001
DPM3-002
DPM3-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DPM3-001
ENSP00000357385
ENST00000368400
Q9P2X0 [Direct mapping]
Dolichol-phosphate mannosyltransferase subunit 3
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004582 [dolichyl-phosphate beta-D-mannosyltransferase activity]
GO:0005515 [protein binding]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005975 [carbohydrate metabolic process]
GO:0006488 [dolichol-linked oligosaccharide biosynthetic process]
GO:0006501 [C-terminal protein lipidation]
GO:0006506 [GPI anchor biosynthetic process]
GO:0016020 [membrane]
GO:0018279 [protein N-linked glycosylation via asparagine]
GO:0018406 [protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan]
GO:0030176 [integral component of endoplasmic reticulum membrane]
GO:0031501 [mannosyltransferase complex]
GO:0031647 [regulation of protein stability]
GO:0033185 [dolichol-phosphate-mannose synthase complex]
GO:0035268 [protein mannosylation]
GO:0035269 [protein O-linked mannosylation]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
Show all
 92 aa
10.1 kDa 		Yes 1
DPM3-002
ENSP00000344338
ENST00000341298
Q9P2X0 [Direct mapping]
Dolichol-phosphate mannosyltransferase subunit 3
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004582 [dolichyl-phosphate beta-D-mannosyltransferase activity]
GO:0005515 [protein binding]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005975 [carbohydrate metabolic process]
GO:0006488 [dolichol-linked oligosaccharide biosynthetic process]
GO:0006501 [C-terminal protein lipidation]
GO:0006506 [GPI anchor biosynthetic process]
GO:0016020 [membrane]
GO:0018279 [protein N-linked glycosylation via asparagine]
GO:0018406 [protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan]
GO:0030176 [integral component of endoplasmic reticulum membrane]
GO:0031501 [mannosyltransferase complex]
GO:0031647 [regulation of protein stability]
GO:0033185 [dolichol-phosphate-mannose synthase complex]
GO:0035268 [protein mannosylation]
GO:0035269 [protein O-linked mannosylation]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
Show all
 92 aa
10.1 kDa 		Yes 1
DPM3-003
ENSP00000357384
ENST00000368399
Q9P2X0 [Direct mapping]
Dolichol-phosphate mannosyltransferase subunit 3
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004582 [dolichyl-phosphate beta-D-mannosyltransferase activity]
GO:0005515 [protein binding]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005975 [carbohydrate metabolic process]
GO:0006488 [dolichol-linked oligosaccharide biosynthetic process]
GO:0006501 [C-terminal protein lipidation]
GO:0006506 [GPI anchor biosynthetic process]
GO:0016020 [membrane]
GO:0018279 [protein N-linked glycosylation via asparagine]
GO:0018406 [protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan]
GO:0030176 [integral component of endoplasmic reticulum membrane]
GO:0031501 [mannosyltransferase complex]
GO:0031647 [regulation of protein stability]
GO:0033185 [dolichol-phosphate-mannose synthase complex]
GO:0035268 [protein mannosylation]
GO:0035269 [protein O-linked mannosylation]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
Show all
 122 aa
13.3 kDa 		Yes 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.