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HES7

CANCER ATLAS

Gene description

 Hes family bHLH transcription factor 7

Protein class

 Disease related genes, Predicted intracellular proteins, Transcription factors

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA072105

GENE INFORMATION

Gene name

 HES7 (HGNC Symbol)

Synonyms

 bHLHb37

Description

 Hes family bHLH transcription factor 7 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the hairy and enhancer of split family of bHLH transcription factors. The mouse ortholog of this gene is regulated by Notch signaling. The protein functions as a transcriptional repressor, and is implicated in correct patterning of the axial skeleton. A mutation in this gene has been shown to result in spondylocostal dysostosis. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]

Chromosome

 17

Cytoband

 p13.1

Chromosome location (bp)

 8120590 - 8124092

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000179111 (version 83.38)

Entrez gene

 84667

UniProt

 Q9BYE0 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9BYE0

Antibodypedia

 HES7 antibodies

PROTEIN BROWSER
HES7-001
HES7-002
HES7-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
HES7-001
ENSP00000446205
ENST00000541682
Q9BYE0 [Direct mapping]
Transcription factor HES-7
Show all
Predicted intracellular proteins
Transcription factors
   Basic domains
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0001501 [skeletal system development]
GO:0001756 [somitogenesis]
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007219 [Notch signaling pathway]
GO:0007498 [mesoderm development]
GO:0008134 [transcription factor binding]
GO:0014807 [regulation of somitogenesis]
GO:0036342 [post-anal tail morphogenesis]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0046983 [protein dimerization activity]
GO:0048511 [rhythmic process]
Show all
 230 aa
25.3 kDa 		No 0
HES7-002
ENSP00000314774
ENST00000317814
Q9BYE0 [Direct mapping]
Transcription factor HES-7
Show all
Predicted intracellular proteins
Transcription factors
   Basic domains
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007498 [mesoderm development]
GO:0008134 [transcription factor binding]
GO:0046983 [protein dimerization activity]
Show all
 225 aa
24.9 kDa 		No 0
HES7-003
ENSP00000462491
ENST00000577735
J3KSH6 [Direct mapping]
Transcription factor HES-7
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0046983 [protein dimerization activity]
Show all
 145 aa
16.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.