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FARSA

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GENERAL INFORMATION

Gene name

 FARSA

Gene description

 Phenylalanyl-tRNA synthetase, alpha subunit

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the cytosol.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Cytosol (supported)

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
HPA001911
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the cytosol.

Main location

 Cytosol (supported)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA001911 A-431 Cytosol
HPA001911 U-251 MG Cytosol

GENE INFORMATION

Gene name

 FARSA (HGNC Symbol)

Synonyms

 CML33, FARSL, FARSLA

Description

 Phenylalanyl-tRNA synthetase, alpha subunit (HGNC Symbol)

Entrez gene summary

 Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. This gene encodes a product which is similar to the catalytic subunit of prokaryotic and Saccharomyces cerevisiae phenylalanyl-tRNA synthetases (PheRS). This gene product has been shown to be expressed in a tumor-selective and cell cycle stage- and differentiation-dependent manner, the first member of the tRNA synthetase gene family shown to exhibit this type of regulated expression [provided by RefSeq, Jul 2008]

Chromosome

 19

Cytoband

 p13.13

Chromosome location (bp)

 12922479 - 12934037

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000179115 (version 83.38)

Entrez gene

 2193

UniProt

 Q9Y285 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9Y285

Antibodypedia

 FARSA antibodies

PROTEIN BROWSER
FARSA-001
FARSA-002
FARSA-005
FARSA-006
FARSA-007
FARSA-010

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
FARSA-001
ENSP00000320309
ENST00000314606
Q9Y285 [Direct mapping]
Phenylalanine--tRNA ligase alpha subunit
Q6IBR2 [Target identity:100%; Query identity:100%]
FARSLA protein; Phenylalanine-tRNA synthetase-like, alpha subunit, isoform CRA_b; cDNA FLJ34774 fis, clone NT2NE2003309, highly similar to Phenylalanyl-tRNA synthetase alpha chain (EC 6.1.1.20)
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Enzymes
   ENZYME proteins
   Ligase
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000049 [tRNA binding]
GO:0000166 [nucleotide binding]
GO:0004812 [aminoacyl-tRNA ligase activity]
GO:0004826 [phenylalanine-tRNA ligase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006418 [tRNA aminoacylation for protein translation]
GO:0006432 [phenylalanyl-tRNA aminoacylation]
GO:0009328 [phenylalanine-tRNA ligase complex]
GO:0010467 [gene expression]
GO:0016020 [membrane]
GO:0043039 [tRNA aminoacylation]
GO:0044822 [poly(A) RNA binding]
Show all
 508 aa
57.6 kDa 		No 0
FARSA-002
ENSP00000396548
ENST00000423140
Q9Y285 [Direct mapping]
Phenylalanine--tRNA ligase alpha subunit
Show all
Enzymes
   ENZYME proteins
   Ligase
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000049 [tRNA binding]
GO:0000166 [nucleotide binding]
GO:0004812 [aminoacyl-tRNA ligase activity]
GO:0004826 [phenylalanine-tRNA ligase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006418 [tRNA aminoacylation for protein translation]
GO:0006432 [phenylalanyl-tRNA aminoacylation]
GO:0009328 [phenylalanine-tRNA ligase complex]
GO:0010467 [gene expression]
GO:0016020 [membrane]
GO:0043039 [tRNA aminoacylation]
GO:0044822 [poly(A) RNA binding]
Show all
 477 aa
54.2 kDa 		No 0
FARSA-005
ENSP00000467384
ENST00000593021
K7EPH2 [Direct mapping]
Phenylalanine--tRNA ligase alpha subunit
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000049 [tRNA binding]
GO:0000166 [nucleotide binding]
GO:0004812 [aminoacyl-tRNA ligase activity]
GO:0004826 [phenylalanine-tRNA ligase activity]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0006418 [tRNA aminoacylation for protein translation]
GO:0006432 [phenylalanyl-tRNA aminoacylation]
GO:0009328 [phenylalanine-tRNA ligase complex]
GO:0043039 [tRNA aminoacylation]
Show all
 379 aa
43.1 kDa 		No 0
FARSA-006
ENSP00000468051
ENST00000588025
K7ER00 [Direct mapping]
Phenylalanine--tRNA ligase alpha subunit
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000049 [tRNA binding]
GO:0000166 [nucleotide binding]
GO:0004812 [aminoacyl-tRNA ligase activity]
GO:0004826 [phenylalanine-tRNA ligase activity]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0006418 [tRNA aminoacylation for protein translation]
GO:0006432 [phenylalanyl-tRNA aminoacylation]
GO:0009328 [phenylalanine-tRNA ligase complex]
GO:0043039 [tRNA aminoacylation]
Show all
 548 aa
62.4 kDa 		No 0
FARSA-007
ENSP00000465402
ENST00000587981
K7EK06 [Direct mapping]
Phenylalanine--tRNA ligase alpha subunit
Show all
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006432 [phenylalanyl-tRNA aminoacylation]
GO:0009328 [phenylalanine-tRNA ligase complex]
Show all
 169 aa
18.5 kDa 		No 0
FARSA-010
ENSP00000468384
ENST00000587488
K7ERS0 [Direct mapping]
Phenylalanine--tRNA ligase alpha subunit
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000049 [tRNA binding]
GO:0004812 [aminoacyl-tRNA ligase activity]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0006432 [phenylalanyl-tRNA aminoacylation]
GO:0009328 [phenylalanine-tRNA ligase complex]
GO:0043039 [tRNA aminoacylation]
Show all
 159 aa
18.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.