Expression of CYP11B2 in cancer - Summary

CANCER ATLAS

Gene description

Cytochrome P450, family 11, subfamily B, polypeptide 2

Protein class

Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA049171	HPA056348	HPA057752

GENE INFORMATION
Gene name	CYP11B2 (HGNC Symbol)
Synonyms	ALDOS, CPN2, CYP11B, CYP11BL, P-450C18, P450aldo
Description	Cytochrome P450, family 11, subfamily B, polypeptide 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the mitochondrial inner membrane. The enzyme has steroid 18-hydroxylase activity to synthesize aldosterone and 18-oxocortisol as well as steroid 11 beta-hydroxylase activity. Mutations in this gene cause corticosterone methyl oxidase deficiency. [provided by RefSeq, Jul 2008]
Chromosome	8
Cytoband	q24.3
Chromosome location (bp)	142910559 - 142917843
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000179142 (version 83.38)
Entrez gene	1585
UniProt	P19099 (UniProt - Evidence at protein level)
neXtProt	NX_P19099
Antibodypedia	CYP11B2 antibodies

PROTEIN BROWSER

CYP11B2-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CYP11B2-001 ENSP00000325822 ENST00000323110	P19099 [Direct mapping] Cytochrome P450 11B2, mitochondrial Show all	Enzymes ENZYME proteins Oxidoreductases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Show all	GO:0002017 [regulation of blood volume by renal aldosterone] GO:0003091 [renal water homeostasis] GO:0004507 [steroid 11-beta-monooxygenase activity] GO:0005506 [iron ion binding] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0006700 [C21-steroid hormone biosynthetic process] GO:0006705 [mineralocorticoid biosynthetic process] GO:0006805 [xenobiotic metabolic process] GO:0008202 [steroid metabolic process] GO:0008203 [cholesterol metabolic process] GO:0016125 [sterol metabolic process] GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen] GO:0016709 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen] GO:0020037 [heme binding] GO:0032342 [aldosterone biosynthetic process] GO:0032870 [cellular response to hormone stimulus] GO:0034651 [cortisol biosynthetic process] GO:0035865 [cellular response to potassium ion] GO:0044281 [small molecule metabolic process] GO:0044550 [secondary metabolite biosynthetic process] GO:0047783 [corticosterone 18-monooxygenase activity] GO:0055075 [potassium ion homeostasis] GO:0055078 [sodium ion homeostasis] GO:0055114 [oxidation-reduction process] GO:0071375 [cellular response to peptide hormone stimulus] Show all	503 aa 57.6 kDa	No	0