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ALOXE3

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GENERAL INFORMATION

Gene name

 ALOXE3

Gene description

 Arachidonate lipoxygenase 3

Protein class

 Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the plasma membrane & cytosol.

RNA cell category

 Cell line enhanced (A-431, hTCEpi, T-47d)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Plasma membrane (approved), Cytosol (approved)

DATA RELIABILITY

Reliability score

 Approved based on 1 antibody.
HPA023120
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (A-431, hTCEpi, T-47d)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the plasma membrane & cytosol.

Main location

 Plasma membrane (approved), Cytosol (approved)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA023120 A-431 Plasma membrane
Cytosol
HPA023120 PC-3 Plasma membrane
Cytosol
HPA023120 U-2 OS Plasma membrane
Cytosol

GENE INFORMATION

Gene name

 ALOXE3 (HGNC Symbol)

Synonyms

 E-LOX, eLOX3

Description

 Arachidonate lipoxygenase 3 (HGNC Symbol)

Entrez gene summary

 This gene is a member of the lipoxygenase family, which are catabolized by arachidonic acid-derived compounds. The encoded enzyme is a hydroperoxide isomerase that synthesizes a unique type of epoxy alcohol (8R-hydroxy-11R,12R-epoxyeicosa-5Z,9E,14Z-trienoic acid) from 12R-hydroperoxyeicosatetraenoic acid (12R-HPETE). This epoxy alcohol can activate the the nuclear receptor peroxisome proliferator-activated receptor alpha (PPARalpha), which is implicated in epidermal differentiation. Loss of function of the enzyme encoded by this gene results in ichthyosis, implicating the function of this gene in the differentiation of human skin. This gene is part of a cluster of lipoxygenase genes on 17p13.1. Mutations in this gene result in nonbullous congenital ichthyosiform erythroderma (NCIE). Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]

Chromosome

 17

Cytoband

 p13.1

Chromosome location (bp)

 8095900 - 8119047

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000179148 (version 83.38)

Entrez gene

 59344

UniProt

 Q9BYJ1 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9BYJ1

Antibodypedia

 ALOXE3 antibodies

PROTEIN BROWSER
ALOXE3-001
ALOXE3-002
ALOXE3-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ALOXE3-001
ENSP00000369494
ENST00000380149
J3KPH2 [Direct mapping]
Arachidonate lipoxygenase 3, isoform CRA_a; Hydroperoxide isomerase ALOXE3
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
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GO:0005515 [protein binding]
GO:0016702 [oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen]
GO:0046872 [metal ion binding]
GO:0055114 [oxidation-reduction process]
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 867 aa
97.8 kDa 		No 0
ALOXE3-002
ENSP00000314879
ENST00000318227
Q9BYJ1 [Direct mapping]
Hydroperoxide isomerase ALOXE3
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Enzymes
   ENZYME proteins
   Lyases
   Isomerase
   SPOCTOPUS predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Show all
GO:0005506 [iron ion binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0006665 [sphingolipid metabolic process]
GO:0016702 [oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen]
GO:0016829 [lyase activity]
GO:0019233 [sensory perception of pain]
GO:0019369 [arachidonic acid metabolic process]
GO:0019372 [lipoxygenase pathway]
GO:0035357 [peroxisome proliferator activated receptor signaling pathway]
GO:0043651 [linoleic acid metabolic process]
GO:0045444 [fat cell differentiation]
GO:0046513 [ceramide biosynthetic process]
GO:0046872 [metal ion binding]
GO:0051120 [hepoxilin A3 synthase activity]
GO:0051122 [hepoxilin biosynthetic process]
GO:0055114 [oxidation-reduction process]
GO:0061436 [establishment of skin barrier]
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 843 aa
95.2 kDa 		No 0
ALOXE3-003
ENSP00000400581
ENST00000448843
Q9BYJ1 [Direct mapping]
Hydroperoxide isomerase ALOXE3
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Enzymes
   ENZYME proteins
   Lyases
   Isomerase
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Show all
GO:0005506 [iron ion binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0006665 [sphingolipid metabolic process]
GO:0016702 [oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen]
GO:0016829 [lyase activity]
GO:0019233 [sensory perception of pain]
GO:0019369 [arachidonic acid metabolic process]
GO:0019372 [lipoxygenase pathway]
GO:0035357 [peroxisome proliferator activated receptor signaling pathway]
GO:0043651 [linoleic acid metabolic process]
GO:0045444 [fat cell differentiation]
GO:0046513 [ceramide biosynthetic process]
GO:0046872 [metal ion binding]
GO:0051120 [hepoxilin A3 synthase activity]
GO:0051122 [hepoxilin biosynthetic process]
GO:0055114 [oxidation-reduction process]
GO:0061436 [establishment of skin barrier]
Show all
 711 aa
80.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.