Tissue expression of CDH4 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	CDH4
Gene description	Cadherin 4, type 1, R-cadherin (retinal)
Protein class	Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (cerebral cortex, spleen)
GTEx:	Tissue enhanced (caudate, ovary)
FANTOM5:	Tissue enhanced (caudate, hippocampus)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (cerebral cortex, spleen)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (caudate, ovary)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (caudate, hippocampus)

GENE INFORMATION
Gene name	CDH4
Synonyms
Description	Cadherin 4, type 1, R-cadherin (retinal) (HGNC Symbol)
Entrez gene summary	This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Based on studies in chicken and mouse, this cadherin is thought to play an important role during brain segmentation and neuronal outgrowth. In addition, a role in kidney and muscle development is indicated. Of particular interest are studies showing stable cis-heterodimers of cadherins 2 and 4 in cotransfected cell lines. Previously thought to interact in an exclusively homophilic manner, this is the first evidence of cadherin heterodimerization. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
Chromosome	20
Cytoband	q13.33
Chromosome location (bp)	61252426 - 61940617
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000179242 (version 83.38)
Entrez gene	1002
UniProt	P55283 (UniProt - Evidence at transcript level)
neXtProt	NX_P55283
Antibodypedia	CDH4 antibodies

PROTEIN BROWSER

CDH4-001	CDH4-002	CDH4-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CDH4-001 ENSP00000484928 ENST00000614565	P55283 [Direct mapping] Cadherin-4 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007155 [cell adhesion] GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules] GO:0007157 [heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules] GO:0007411 [axon guidance] GO:0016020 [membrane] GO:0034329 [cell junction assembly] GO:0034332 [adherens junction organization] GO:0045216 [cell-cell junction organization] GO:0045773 [positive regulation of axon extension] Show all	916 aa 100.3 kDa	Yes	1
CDH4-002 ENSP00000480844 ENST00000611855	A0A087WX99 [Direct mapping] Cadherin-4 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0005509 [calcium ion binding] GO:0005886 [plasma membrane] GO:0007155 [cell adhesion] GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	822 aa 90.1 kDa	No	1
CDH4-003 ENSP00000443301 ENST00000543233	P55283 [Direct mapping] Cadherin-4 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005886 [plasma membrane] GO:0007155 [cell adhesion] GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules] GO:0016020 [membrane] GO:0034329 [cell junction assembly] GO:0034332 [adherens junction organization] GO:0045216 [cell-cell junction organization] Show all	842 aa 92.4 kDa	No	1