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RAD23A

CANCER ATLAS

Gene description

 RAD23 homolog A, nucleotide excision repair protein

Protein class

 Cancer-related genes, Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Urothelial cancer

STAINING SUMMARY
HPA065599

GENE INFORMATION

Gene name

 RAD23A (HGNC Symbol)

Synonyms

 HHR23A, MGC111083

Description

 RAD23 homolog A, nucleotide excision repair protein (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is one of two human homologs of Saccharomyces cerevisiae Rad23, a protein involved in nucleotide excision repair. Proteins in this family have a modular domain structure consisting of an ubiquitin-like domain (UbL), ubiquitin-associated domain 1 (UbA1), XPC-binding domain and UbA2. The protein encoded by this gene plays an important role in nucleotide excision repair and also in delivery of polyubiquitinated proteins to the proteasome. Alternative splicing results in multiple transcript variants encoding multiple isoforms. [provided by RefSeq, Jun 2012]

Chromosome

 19

Cytoband

 p13.13

Chromosome location (bp)

 12945855 - 12953642

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000179262 (version 83.38)

Entrez gene

 5886

UniProt

 P54725 (UniProt - Evidence at protein level)

neXtProt

 NX_P54725

Antibodypedia

 RAD23A antibodies

PROTEIN BROWSER
RAD23A-001
RAD23A-002
RAD23A-005
RAD23A-008

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RAD23A-001
ENSP00000321365
ENST00000316856
P54725 [Direct mapping]
UV excision repair protein RAD23 homolog A
Show all
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000502 [proteasome complex]
GO:0003684 [damaged DNA binding]
GO:0003697 [single-stranded DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006289 [nucleotide-excision repair]
GO:0016032 [viral process]
GO:0031593 [polyubiquitin binding]
GO:0032434 [regulation of proteasomal ubiquitin-dependent protein catabolic process]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0045070 [positive regulation of viral genome replication]
GO:1990381 [ubiquitin-specific protease binding]
Show all
 362 aa
39.5 kDa 		No 0
RAD23A-002
ENSP00000467024
ENST00000586534
P54725 [Direct mapping]
UV excision repair protein RAD23 homolog A
A0A024R7G8 [Target identity:100%; Query identity:100%]
RAD23 homolog A (S. cerevisiae), isoform CRA_a
Show all
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000502 [proteasome complex]
GO:0003684 [damaged DNA binding]
GO:0003697 [single-stranded DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006289 [nucleotide-excision repair]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0016032 [viral process]
GO:0031593 [polyubiquitin binding]
GO:0032434 [regulation of proteasomal ubiquitin-dependent protein catabolic process]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0045070 [positive regulation of viral genome replication]
GO:1990381 [ubiquitin-specific protease binding]
Show all
 363 aa
39.6 kDa 		No 0
RAD23A-005
ENSP00000468674
ENST00000592268
P54725 [Direct mapping]
UV excision repair protein RAD23 homolog A
Show all
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000502 [proteasome complex]
GO:0003684 [damaged DNA binding]
GO:0003697 [single-stranded DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006289 [nucleotide-excision repair]
GO:0016032 [viral process]
GO:0031593 [polyubiquitin binding]
GO:0032434 [regulation of proteasomal ubiquitin-dependent protein catabolic process]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0045070 [positive regulation of viral genome replication]
GO:1990381 [ubiquitin-specific protease binding]
Show all
 308 aa
33.4 kDa 		No 0
RAD23A-008
ENSP00000467628
ENST00000590881
K7EQ16 [Direct mapping]
UV excision repair protein RAD23 homolog A
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003684 [damaged DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006289 [nucleotide-excision repair]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
Show all
 150 aa
16.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.